Evidence map›Paper›PMID 29176904›Full record

ArticlePloS one2017

Mobile microscopy as a screening tool for oral cancer in India: A pilot study.

Arunan Skandarajah, Sumsum P Sunny, Praveen Gurpur, Clay D Reber, Michael V D'Ambrosio, Nisheena Raghavan, Bonney Lee James, Ravindra D Ramanjinappa, Amritha Suresh, Uma Kandasarma and 13 more

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  20. Current Insights into Oral Cancer Diagnostics.Diagnostics (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Arunan SkandarajahDepartment of Bioengineering, University of California, Berkeley, CA, United States of America.
Sumsum P SunnyHead and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.
Praveen GurpurSiemens Healthcare Pvt Ltd, Bangalore, India.
Clay D ReberDepartment of Bioengineering, University of California, Berkeley, CA, United States of America.
Michael V D'AmbrosioDepartment of Bioengineering, University of California, Berkeley, CA, United States of America.
Nisheena RaghavanDepartment of Pathology, Mazumdar Shaw Medical Centre, NH Health City, Bangalore, India.
Bonney Lee JamesIntegrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.
Ravindra D RamanjinappaIntegrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.
Amritha SureshHead and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.
Uma KandasarmaDepartment of Oral and Maxillofacial Pathology, KLE Society's Institute of Dental Sciences, Bangalore, India.
Praveen BirurDepartment of oral medicine and radiology, KLE Society's Institute of Dental Sciences, Bangalore, India.
Vinay V KumarHead and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.
Honorius-Cezar GalmeanuSiemens S.R.L, Brasov, Romania.
Alexandru Mihail ItuSiemens S.R.L, Brasov, Romania.
Mihai Modiga-ArsuSiemens S.R.L, Brasov, Romania.
Saskia RauschSiemens Healthcare GmbH, Erlangen, Germany.
Maria SramekSiemens Healthcare GmbH, Erlangen, Germany.
Manohar KollegalSiemens Healthcare Pvt Ltd, Bangalore, India.
Gianluca PaladiniSiemens Medical Solutions USA Inc., Princeton, NJ, United States of America.
Moni KuriakoseHead and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.
Lance LadicSiemens Medical Solutions USA Inc., Princeton, NJ, United States of America.ORCID http://orcid.org/0000-0002-8900-2701
Felix KochDepartment of Oral and Maxillofacial Surgery-Plastic Surgery, University of Mainz, Mainz, Germany.
Daniel FletcherDepartment of Bioengineering, University of California, Berkeley, CA, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer is the most common type of cancer among men in India and other countries in South Asia. Late diagnosis contributes significantly to this mortality, highlighting the need for effective and specific point-of-care diagnostic tools. The same regions with high prevalence of oral cancer have seen extensive growth in mobile phone infrastructure, which enables widespread access to telemedicine services. In this work, we describe the evaluation of an automated tablet-based mobile microscope as an adjunct for telemedicine-based oral cancer screening in India. Brush biopsy, a minimally invasive sampling technique was combined with a simplified staining protocol and a tablet-based mobile microscope to facilitate local collection of digital images and remote evaluation of the images by clinicians. The tablet-based mobile microscope (CellScope device) combines an iPad Mini with collection optics, LED illumination and Bluetooth-controlled motors to scan a slide specimen and capture high-resolution images of stained brush biopsy samples. Researchers at the Mazumdar Shaw Medical Foundation (MSMF) in Bangalore, India used the instrument to collect and send randomly selected images of each slide for telepathology review. Evaluation of the concordance between gold standard histology, conventional microscopy cytology, and remote pathologist review of the images was performed as part of a pilot study of mobile microscopy as a screening tool for oral cancer. Results indicated that the instrument successfully collected images of sufficient quality to enable remote diagnoses that show concordance with existing techniques. Further studies will evaluate the effectiveness of oral cancer screening with mobile microscopy by minimally trained technicians in low-resource settings.

Indexed as

Cell PhoneAdultAgedAutomationDemographyEarly Detection of CancerFemaleHumansImage Processing, Computer-AssistedIndiaMaleMicroscopyMiddle AgedMouth NeoplasmsPilot ProjectsSensitivity and Specificity

Identifiers

PMID29176904
PMCPMC5703562

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.