ArticlePloS one2017
Persistent abnormalities in pulmonary arterial compliance after heart transplantation in patients with combined post-capillary and pre-capillary pulmonary hypertension.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic.The international journal of cardiovascular imaging · 2026Article
- The pulmonary resistance-compliance relationship: Real or mathematical artifact?Physiological reports · 2025Article
- How does severe functional mitral regurgitation redefined by European guidelines affect pulmonary vascular resistance and hemodynamics in heart transplant candidates?Anatolian journal of cardiology · 2021Article
- Prognostic value of exercise myocardial deformation and haemodynamics in long-term heart-transplanted patients.ESC heart failure · 2019Article
- Pulmonary Hypertension Due to Left Heart Disease: an Update.Current cardiology reports · 2019Review
- Pulmonary arterial compliance is a useful predictor of pulmonary vascular disease in congenital heart disease.Heart and vessels · 2019Article
- Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues.ESC heart failure · 2018Review
- Complications of Cardiac Transplantation.Current cardiology reports · 2018Review
- Pulsatile operation of a continuous-flow right ventricular assist device (RVAD) to improve vascular pulsatility.PloS one · 2018Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hemodynamic definitions of pulmonary hypertension (PH) in left heart disease have recently been refined to better match the characteristics required to reflect the presence of pulmonary vascular disease. Accordingly, we tested the hypothesis that abnormalities in the stiffness of pulmonary circulation would persist after heart transplantation in patients with combined post-capillary and pre-capillary PH (Cpc-PH) in contrast to those with isolated post-capillary PH (Ipc-PH).
methodsWe retrospectively analyzed right heart hemodynamics in a cohort of 295 consecutive patients with heart failure and advanced left ventricular systolic dysfunction (LVSD) before and 1 year after heart transplantation.
resultsAccording to their baseline hemodynamic profile, patients were classified as: 75 Cpc-PH, 111 Ipc-PH, and 98 without PH (no-PH), and 11 pre-capillary PH. One year after heart transplantation, pulmonary artery pressures, pulmonary vascular resistance and cardiac index normalized in all patients regardless of the baseline hemodynamic profile. However, pulmonary arterial compliance remained lower in Cpc-PH patients (from 1.6±1.2 at baseline to 3.7±1.4 ml/mmHg at 1 year) than in Ipc-PH (from 1.2±2.0 to 4.4±2.3 ml/mmHg) and no-PH patients (from 3.7±2.0 to 4.5±1.8 ml/mmHg); (adjusted p = 0.03 Ipc-PH vs. Cpc-PH INT<0.001).
conclusionsIn heart failure patients with advanced LVSD, a hemodynamic profile characterized by Cpc-PH predicts the persistence of a stiffer pulmonary circulation at 1 year after heart transplantation.
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