ArticlePloS one2017
Promising new vaccine candidates against Campylobacter in broilers.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and antimicrobial resistance patterns of Campylobacter spp. Causing human gastroenteritis in Iran (2000-2025): a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Preharvest Control ofMicroorganisms · 2025Review
- Therapeutic and protective approaches to combatFrontiers in pharmacology · 2025Review
- Consortium ofAntibiotics (Basel, Switzerland) · 2024Article
- Campylobacter jejuni virulence factors: update on emerging issues and trends.Journal of biomedical science · 2024Review
- Design of a multi-epitope-based vaccine candidate against Bovine Genital Campylobacteriosis using a reverse vaccinology approach.BMC veterinary research · 2024Article
- Evaluation of Two Recombinant Protein-Based Vaccine Regimens againstAnimals : an open access journal from MDPI · 2023Article
- Plasmid DNA Prime/Protein Boost Vaccination againstPharmaceutics · 2023Article
- In silico prediction and expression analysis of vaccine candidate genes of Campylobacter jejuni.Poultry science · 2023Article
- Intervention Strategies to ControlMicroorganisms · 2023Review
- Antimicrobial effect of a drinking water additive comprising four organic acids on Campylobacter load in broilers and monitoring of bacterial susceptibility.Poultry science · 2022Article
- Impact of DNA Prime/Protein Boost Vaccination againstVaccines · 2022Article
- Mechanisms of biodiversity betweenEcology and evolution · 2022Article
- Impact of the gut microecology on Campylobacter presence revealed by comparisons of the gut microbiota from chickens raised on litter or in individual cages.BMC microbiology · 2021Article
- A Systematic Review ofMicroorganisms · 2021Review
- Management Strategies for Prevention of Campylobacter Infections Through the Poultry Food Chain: A European Perspective.Current topics in microbiology and immunology · 2021Article
- In silico analysis of epitope-based CadF vaccine design against Campylobacter jejuni.BMC research notes · 2020Article
- Update and review of control options for Campylobacter in broilers at primary production.EFSA journal. European Food Safety Authority · 2020Article
- Novel ClinicalMicroorganisms · 2020Review
- Current Perspectives and Potential of Probiotics to Limit FoodborneFrontiers in microbiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1) significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.