ArticlePLoS neglected tropical diseases2017
Cross-sectional interview study of fertility, pregnancy, and urogenital schistosomiasis in coastal Kenya: Documented treatment in childhood is associated with reduced odds of subfertility among adult women.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association of schistosomiasis and HIV infections: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- SCORE Studies on the Impact of Drug Treatment on Morbidity due toThe American journal of tropical medicine and hygiene · 2020Pooled it
- Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women Infected with Schistosoma japonicum.Antimicrobial agents and chemotherapy · 2020Trial
- Sex-specific presentation, epidemiology, and control of schistosomiasis in women and adolescent girls.The Lancet. Global health · 2026Review
- Female genital schistosomiasis-related infertility and gynecological manifestations among women living in countries endemic for urogenital schistosomiasis in Africa: systematic review and meta-analysis protocol.Systematic reviews · 2026Article
- Association of Schistosoma haematobium Infection With Decreased Pregnancy: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- 'Female Genital Schistosomiasis: Translational Challenges and Opportunities' - outputs and actions from a consultative, collaborative and translational workshop.Parasitology · 2025Review
- Genital schistosomiasis in non-endemic settings: a clinical perspective.Parasitology · 2025Review
- Schistosomiasis: a neglected cause of infertility in females and males.Current opinion in infectious diseases · 2025Review
- Nationwide prevalence of infertility in Iranian couples: findings from a 2019 study.BMC public health · 2025Article
- Female Genital Schistosomiasis (FGS) in a Nonendemic Setting: Retrospective Case-Notes Review ofOpen forum infectious diseases · 2025Article
- Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms.Journal of tropical medicine · 2025Review
- Pediatric urogenital schistosomiasis diagnosed in France.Pediatric nephrology (Berlin, Germany) · 2024Article
- Integration of female genital schistosomiasis into HIV/sexual and reproductive health and rights and neglected tropical diseases programmes and services: a scoping review.Sexual and reproductive health matters · 2023Article
- Assessing the prevalence of Female Genital Schistosomiasis and comparing the acceptability and performance of health worker-collected and self-collected cervical-vaginal swabs using PCR testing among women in North-Western Tanzania: The ShWAB study.PLoS neglected tropical diseases · 2023Article
- Improving the Response of Health Systems to Female Genital Schistosomiasis in Endemic Countries through a Gender-Sensitive Human Rights-Based Framework.Diseases (Basel, Switzerland) · 2022Article
- Absence of lower genital tract lesions among women of reproductive age infected with Schistosoma mansoni: A cross-sectional study using a colposcope in Western Kenya.PLoS neglected tropical diseases · 2022Article
- Schistosomiasis, soil transmitted helminthiasis, and malaria co-infections among women of reproductive age in rural communities of Kwale County, coastal Kenya.BMC public health · 2022Article
- Beyond the barrier: Female Genital Schistosomiasis as a potential risk factor for HIV-1 acquisition.Acta tropica · 2020Review
- Genital self-sampling compared with cervicovaginal lavage for the diagnosis of female genital schistosomiasis in Zambian women: The BILHIV study.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrevious research has documented an increased risk of subfertility in areas of sub-Saharan Africa, as well as an ecological association between urogenital schistosomiasis prevalence and decreased fertility. This pilot project examined reproductive patterns and the potential effects of childhood urogenital Schistosoma haematobium infection and individual treatment experience on adult subfertility among women who were long-term residents in an S. haematobium-endemic region of coastal Kenya. METHODOLOGY/PRINCIPAL
findingsWe analyzed findings from 162 in-depth interviews with women of childbearing age in a rural, coastal community, linking them, if possible, to their individual treatment records from previous multi-year longitudinal studies of parasitic infections. Reproductive histories indicated a much local higher local rate of subfertility (44%) than worldwide averages (8-12%). Although, due to the very high regional prevalence of schistosomiasis, a clear relationship could not be demonstrated between a history of S. haematobium infection and adult subfertility, among a convenience sub-sample of 61 women who had received documented treatment during previous interventional trials, a significant association was found between age at first anti-schistosomal treatment and later fertility in adulthood, with those women treated before age 21 significantly less likely to have subfertility (P = 0.001). CONCLUSIONS/SIGNIFICANCE: The high subfertility rate documented in this pilot study suggests the importance of programs to prevent and treat pelvic infections in their early stages to preclude reproductive tract damage. The available documented treatment data also suggest that early anti-schistosomal treatment may prevent the fertility-damaging effects of urogenital schistosomiasis, and lend support for programs that provide universal treatment of children in S. haematobium-endemic regions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.