ArticleNature communications2017
A very large-scale microelectrode array for cellular-resolution electrophysiology.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- High-channel-count neural recording and stimulation platform with 5376 simultaneous recording channels.npj biomedical innovations · 2026Article
- Microelectrode array scaled for human hippocampal slices.Epilepsia open · 2026Article
- High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels.bioRxiv : the preprint server for biology · 2026Article
- Nanomaterial based photoacoustic interface for non-genetic neuromodulation.Nano futures · 2026Review
- Toward continuous monitoring systems: emerging trends of on-chip sensors in organ-on-a-chip.Microsystems & nanoengineering · 2026Review
- Brain organoids-on-chip for neural diseases modeling: History, challenges and trends.Journal of pharmaceutical analysis · 2025Review
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- AAV-mediated gene therapy for focal epilepsy by expressing neuropeptide Y and Y2 receptor in rodent and non-human primate hippocampus.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array.Nature biomedical engineering · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Advanced passive 3D bioelectronics: powerful tool for the cardiac electrophysiology investigation.Microsystems & nanoengineering · 2025Review
- High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons.Scientific reports · 2025Article
- Direct-Print 3D Electrodes for Large-Scale, High-Density, and Customizable Neural Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Platinum Wire-Embedded Culturing Device for Interior Signal Recording from Lollipop-Shaped Neural Spheroids.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- 360° size-adjustable microelectrode array system for electrophysiological monitoring of cerebral organoids.Frontiers in bioengineering and biotechnology · 2025Article
- A 4096 channel event-based multielectrode array with asynchronous outputs compatible with neuromorphic processors.Nature communications · 2024Article
- Photoacoustic: A Versatile Nongenetic Method for High-Precision Neuromodulation.Accounts of chemical research · 2024Review
- Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants.Science advances · 2024Article
- Review
- Large-Area Field Potential Imaging Having Single Neuron Resolution Using 236 880 Electrodes CMOS-MEA Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In traditional electrophysiology, spatially inefficient electronics and the need for tissue-to-electrode proximity defy non-invasive interfaces at scales of more than a thousand low noise, simultaneously recording channels. Using compressed sensing concepts and silicon complementary metal-oxide-semiconductors (CMOS), we demonstrate a platform with 65,536 simultaneously recording and stimulating electrodes in which the per-electrode electronics consume an area of 25.5 μm by 25.5 μm. Application of this platform to mouse retinal studies is achieved with a high-performance processing pipeline with a 1 GB/s data rate. The platform records from 65,536 electrodes concurrently with a ~10 µV r.m.s. noise; senses spikes from more than 34,000 electrodes when recording across the entire retina; automatically sorts and classifies greater than 1700 neurons following visual stimulation; and stimulates individual neurons using any number of the 65,536 electrodes while observing spikes over the entire retina. The approaches developed here are applicable to other electrophysiological systems and electrode configurations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.