ArticleScientific reports2017
Mechanistic insight to ROS and Apoptosis regulated cytotoxicity inferred by Green synthesized CuO nanoparticles from Calotropis gigantea to Embryonic Zebrafish.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- From traditional uses to biochemical evidence: phytochemical diversity and bioactivities of Calotropis gigantea-a comprehensive update since 2013.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
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- Graphene oxide-microplastic hybrid showcase elicited discrepancy through intrinsic interaction mediated steatosis, and apoptosis in macrophages.Materials today. Bio · 2026Article
- Mechanistic paradigms of teratogenicity induced by metallic nanoparticles-a mini review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Equal nano-characteristics, unequal harm: the chemical composition of noble metal nanoparticles as the main factor of cytotoxicity.Frontiers in toxicology · 2026Article
- Efficacy of Haloxyfop-R-Methyl on Allium cepa: Cyto-Genotoxic and In Silico Docking Studies on the Mechanism of Action.Microscopy research and technique · 2025Article
- Assessment of antimicrobial efficacy of leather coating using chitosan modified TiORSC advances · 2025Article
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- Transformation of Engineered Copper Oxide Nanoparticles in Surface Waters.Journal of xenobiotics · 2024Article
- Biosynthesis of copper nanoparticles using Solenostemma argel and their effect on enhancing salt tolerance in barley plants.Scientific reports · 2024Article
- Cupric-polymeric nanoreactors integrate into copper metabolism to promote chronic diabetic wounds healing.Materials today. Bio · 2024Article
- Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles.Molecules (Basel, Switzerland) · 2024Review
- Green and cost-effective biofabrication of copper oxide nanoparticles: Exploring antimicrobial and anticancer applications.Biotechnology reports (Amsterdam, Netherlands) · 2024Review
- Biogenic Zinc Oxide Nanoparticles synthesized fromNanotheranostics · 2024Article
- Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak.Chemicke zvesti · 2023Review
- The translational paradigm of nanobiomaterials: Biological chemistry to modern applications.Materials today. Bio · 2022Review
- Article
- Inactivation of various variant types of SARS-CoV-2 by indoor-light-sensitive TiOScientific reports · 2022Article
- Effect of magnetic field on the removal of copper from aqueous solution using activated carbon derived from rice husk.Environmental science and pollution research international · 2022Article
- Article
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7 authors.
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Abstract
With the rapid development of nanotechnology, much has been anticipated with copper oxide nanoparticles (CuO NP) due to their extensive industrial and commercial application. However, it has raised concern over the environmental safety and human health effects. In this study, CuO nanoparticles were synthesized using the green method with floral extract of Calotropis gigantea and characterized by standard physiochemical techniques like DLS, Zeta potential determination, UV- Visible Spectroscopy, XRD, FTIR, FESEM, and TEM. Mechanistic cytotoxicity studies were performed using experimental and computational assays including morphological analysis, hatching, and viability rate analysis along with ROS and apoptosis analysis. Physiochemical characterization of CuO NP determined the size and zeta potential of synthesized nanoparticles to be 30 ± 09 nm to 40 ± 2 nm and -38 mV ± 12 mV respectively. Cytotoxicity evaluation with Zebrafish revealed malfunctioned organ development with differential viability and hatching rate at 48 hpf and 72 hpf with LC50 of 175 ± 10 mg/l. Computational analysis depicted the influential role of CuO nanoparticles on zebrafish embryo's he1a, sod1 and p53 functional expression through hydrophobic and hydrogen bond interaction with amino acid residues. Study demonstrated valuable information of cytotoxic impact which can be influential in further studies of their eco-toxicological effects.
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