ArticleScientific reports2017
Avian Influenza H5N6 Viruses Exhibit Differing Pathogenicities and Transmissibilities in Mammals.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The H5N6 Virus Containing Internal Genes From H9N2 Exhibits Enhanced Pathogenicity and Transmissibility.Transboundary and emerging diseases · 2025Article
- Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine.Emerging infectious diseases · 2024Article
- Clade 2.3.4.4 H5 chimeric cold-adapted attenuated influenza vaccines induced cross-reactive protection in mice and ferrets.Journal of virology · 2023Article
- Article
- Pathogenicity and Transmissibility of Clade 2.3.4.4h H5N6 Avian Influenza Viruses in Mammals.Animals : an open access journal from MDPI · 2022Article
- Next-Generation Computationally Designed Influenza Hemagglutinin Vaccines Protect against H5Nx Virus Infections.Pathogens (Basel, Switzerland) · 2021Article
- Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses.Emerging infectious diseases · 2021Article
- Risk of Environmental Exposure to H7N9 Influenza VirusFrontiers in cellular and infection microbiology · 2021Article
- Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model.Antimicrobial agents and chemotherapy · 2020Article
- Identification of cellular microRNA miR-188-3p with broad-spectrum anti-influenza A virus activity.Virology journal · 2020Article
- Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs.Scientific reports · 2019Article
- The Emergence and Decennary Distribution of Clade 2.3.4.4 HPAI H5Nx.Microorganisms · 2019Review
- A Novel Reassortant Avian H7N6 Influenza Virus Is Transmissible in Guinea Pigs via Respiratory Droplets.Frontiers in microbiology · 2019Article
- A review of H5Nx avian influenza viruses.Therapeutic advances in vaccines and immunotherapy · 2019Review
- Patient-derived avian influenza A (H5N6) virus is highly pathogenic in mice but can be effectively treated by anti-influenza polyclonal antibodies.Emerging microbes & infections · 2018Article
- Avian influenza overview November 2017 - February 2018.EFSA journal. European Food Safety Authority · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2013, highly pathogenic avian influenza H5N6 viruses have emerged in poultry and caused sporadic infections in humans, increasing global concerns regarding their potential as human pandemic threats. Here, we characterized the receptor-binding specificities, pathogenicities and transmissibilities of three H5N6 viruses isolated from poultry in China. The surface genes hemagglutinin (HA) and neuraminidase (NA) were closely related to the human-originating strain A/Changsha/1/2014 (H5N6). Phylogenetic analyses showed that the HA genes were clustered in the 2.3.4.4 clade, and the NA genes were derived from H6N6 viruses. These H5N6 viruses bound both α-2,3-linked and α-2,6-linked sialic acid receptors, but they exhibited different pathogenicities in mice. In addition, one virus was fully infective and transmissible by direct contact in guinea pigs. These results highlight the importance of monitoring the continual adaptation of H5N6 viruses in poultry due to their potential threat to human health.
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