ReviewCurrent opinion in anaesthesiology2018
Vitamin C in sepsis.
Review in Current opinion in anaesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis.International journal of clinical practice · 2023Pooled it
- Mortality in septic patients treated with vitamin C: a systematic meta-analysis.Critical care (London, England) · 2021Pooled it
- Efficacy of Ascorbic Acid, Thiamine, and Hydrocortisone Combination Therapy: Meta-analysis of Randomized Controlled Trials.In vivo (Athens, Greece)Pooled it
- Effect of vitamin C in critically ill patients with sepsis and septic shock: A meta-analysis.Science progressPooled it
- Vitamin C in Sepsis: Exploring Its Role in Modulating Inflammation and Oxidative Stress.Cureus · 2025Article
- Melatonin Exerts Positive Effects on Sepsis Through Various Beneficial Mechanisms.Drug design, development and therapy · 2025Review
- Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study.BMC medicine · 2024Observational
- Causal effects of genetically vitamins and sepsis risk: a two-sample Mendelian randomization study.BMC infectious diseases · 2023Article
- Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- The effect of vitamin C in adults with sepsis: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Review
- Curcumin and Vitamin C Attenuate Gentamicin-Induced Nephrotoxicity by Modulating Distinctive Reactive Species.Metabolites · 2022Article
- Review
- Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with Mycobacterium tuberculosis.Experimental and therapeutic medicine · 2022Article
- The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis.Vaccines · 2022Review
- Article
- Ascorbic acid attenuates activation and cytokine production in sepsis-like monocytes.Journal of leukocyte biology · 2022Article
- The Variable Nature of Vitamin C-Does It Help When Dealing with Coronavirus?Antioxidants (Basel, Switzerland) · 2022Review
- Oxygen therapy for sepsis and prevention of complications.Acute and critical care · 2022Article
- The Interplay between Host Defense, Infection, and Clinical Status in Septic Patients: A Narrative Review.International journal of molecular sciences · 2022Review
- Micro but mighty-Micronutrients in the epigenetic regulation of adaptive immune responses.Immunological reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purpose of reviewThis narrative review summarizes recent insights into the role of vitamin C in sepsis. RECENT
findingsSeptic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention. SUMMARY: In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.