Evidence map›Paper›PMID 29175955›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization.

Natasha Khatri, James P Gilbert, Yuda Huo, Roozhin Sharaflari, Michael Nee, Hui Qiao, Heng-Ye Man

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration.International journal of molecular sciences · 2025
    Review
  8. Cortex-SpecificThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Article
  10. Article
  11. Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. HeterozygousHeliyon · 2024
    Article
  19. Autism risk geneFrontiers in cellular neuroscience · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Natasha KhatriDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
James P GilbertDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
Yuda HuoDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
Roozhin SharaflariDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
Michael NeeDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
Hui QiaoDepartment of Biology, Boston University, Boston, Massachusetts 02215, and.
Heng-Ye ManDepartment of Biology, Boston University, Boston, Massachusetts 02215, and hman@bu.edu.ORCID 0000-0002-3530-3066
Boston University · US

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
Molecular Mechanisms of Homeostatic Synaptic PlasticityR01MH079407 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2008 to 2018
$3.9M
NIGMS NIH HHS T32 GM008541NIMH NIH HHS R01 MH079407
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autism Spectrum DisorderAnimalsCaspase 3DNA Copy Number VariationsFemaleGene DosageHEK293 CellsHumansMaleMiceMice, TransgenicMicrotubulesNeuronal PlasticityUbiquitin-Protein LigasesX-Linked Inhibitor of Apoptosis ProteinCaspase 3Ube3a protein, mouseUbiquitin-Protein LigasesX-Linked Inhibitor of Apoptosis ProteinASDdendritic remodelingdevelopmental disorderneuronal developmentUBE3A/E6APubiquitination

Identifiers

PMID29175955
PMCPMC5761614
OpenAlexW2770301415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.