Evidence map›Paper›PMID 29175553›Full record

ReviewBiochimica et biophysica acta. Reviews on cancer2018

The key role of extracellular vesicles in the metastatic process.

Hongyun Zhao, Abhinav Achreja, Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Deepak Nagrath, Stefano Fais

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta. Reviews on cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 160 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. The role of cuproptosis in gastric cancer.Frontiers in immunology · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Hongyun ZhaoBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: hyzhao@umich.edu.
Abhinav AchrejaBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: aachreja@umich.edu.
Elisabetta IessiDepartment of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy. Electronic address: elisabetta.iessi@iss.it.
Mariantonia LogozziDepartment of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy. Electronic address: mariantonia.logozzi@iss.it.
Davide MizzoniDepartment of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy. Electronic address: davide.mizzoni@iss.it.
Rossella Di RaimoDepartment of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy.
Deepak NagrathBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: dnagrath@umich.edu.
Stefano FaisDepartment of Oncology and Molecular Medicine, National Institute of Health, viale Regina Elena 299, 00161, Rome, Italy. Electronic address: stefano.fais@iss.it.
Istituto Superiore di Sanità · ITUniversity of Michigan · US

Funding

Targeting Stromal Influences on Glutamine Addiction in Ovarian CancerR01CA227622 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOK, SAMUEL C, NAGRATH, DEEPAK · 2018 to 2022
$2.3M
Uncovering Role of Exosomes in Regulating Pancreatic Cancer Cell MetabolismR01CA204969 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAGRATH, DEEPAK · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA204969NCI NIH HHS R01 CA227622
6 · The paper itself

Abstract

Extracellular vesicles (EVs), including exosomes, have a key role in the paracrine communication between organs and compartments. EVs shuttle virtually all types of biomolecules such as proteins, lipids, nucleic acids, metabolites and even pharmacological compounds. Their ability to transfer their biomolecular cargo into target cells enables EVs to play a key role in intercellular communication that can regulate cellular functions such as proliferation, apoptosis and migration. This has led to the emergence of EVs as a key player in tumor growth and metastasis through the formation of "tumor niches" in target organs. Recent data have also been shown that EVs may transform the microenvironment of primary tumors thus favoring the selection of cancer cells with a metastatic behavior. The release of EVs from resident non-malignant cells may contribute to the metastatic processes as well. However, cancer EVs may induce malignant transformation in resident mesenchymal stem cells, suggesting that the metastatic process is not exclusively due to circulating tumor cells. In this review, we outline and discuss evidence-based roles of EVs in actively regulating multiple steps of the metastatic process and how we can leverage EVs to impair metastasis.

Indexed as

AnimalsCell CommunicationCell Transformation, NeoplasticDisease ProgressionExtracellular VesiclesHumansNeoplasm MetastasisNeoplasmsTumor MicroenvironmentExosomesExtracellular vesiclesMetastasisMetastatic nicheTumor metabolismTumor microenvironment

Identifiers

PMID29175553
PMCPMC5800973
OpenAlexW2769413428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.