ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2018
Field performance of the Determine HBsAg point-of-care test for diagnosis of hepatitis B virus co-infection among HIV patients in Zambia.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Prevalence of hepatitis B among childbearing women and infant born to HBV-positive mothers in Togo.BMC infectious diseases · 2020Article
- Review
- Article
- HIV, syphilis and hepatitis B coinfections in Mkushi, Zambia: a cross-sectional study.F1000Research · 2019Article
- Community-based sero-prevalence of hepatitis B and C infections in South Omo Zone, Southern Ethiopia.PloS one · 2019Article
- High prevalence of binge drinking among people living with HIV in four African countries.Journal of the International AIDS Society · 2018Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundWe evaluated the field performance of a rapid point-of-care (POC) test for hepatitis B surface antigen (HBsAg) that could support decentralization and scale-up of hepatitis B virus (HBV) diagnosis in Africa.
objectiveTo determine the field performance of the Determine HBsAg POC test for diagnosis of HBV co-infection among HIV patients in Zambia. STUDY
designBetween 2013-2014, we screened HIV-infected adults for HBsAg at two urban clinics in Zambia. A subset were tested with the POC Determine HBsAg (Alere, USA) by finger prick in the clinic and HBsAg serology (Access2Analyzer, Beckman Coulter) at a reference laboratory. If either test was reactive, we determined HBV viral load (VL) and genotype. We described patient demographic and clinical characteristics (including liver fibrosis) and assessed the sensitivity, specificity, positive and negative predictive values (PPV and NPV) of the Determine test. In secondary analyses, we assessed sensitivity among patients with replicating HBV (i.e., VL>20 IU/ml) and with high HBV VL (i.e.,>20,000IU/ml).
resultsAmong 412 participants with both HBsAg tests, median age was 34 years, 51% were women, and median CD4 was 208 cells/mm
conclusionsDetermine HBsAg is a cheaper alternative HBV testing option compared to the gold standard ELISA and has high specificity and good sensitivity in the field among HIV-infected individuals.
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