Observational studyPregnancy hypertension2018
Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.
Observational study in Pregnancy hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Assessing patient-level risk factors for evidence-based early diagnosis of maternal sepsis.BMC pregnancy and childbirth · 2025Article
- Obstetric-specific compared to general early warning system for predicting severe postpartum maternal morbidity.Biomolecules & biomedicine · 2025Article
- Variations in emergency care for severe pre-eclampsia in Uganda: a national evaluation study.AJOG global reports · 2025Article
- Implementation challenges in preeclampsia care: perspectives from health care professionals in urban Uganda.AJOG global reports · 2024Article
- Article
- Establishment of a nomogram model for predicting adverse outcomes in advanced-age pregnant women with preterm preeclampsia.BMC pregnancy and childbirth · 2022Article
- Article
- The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network's first protocol: deep phenotyping in three sub-Saharan African countries.Reproductive health · 2020Article
- Development of an early-warning system for high-risk patients for suicide attempt using deep learning and electronic health records.Translational psychiatry · 2020Article
- Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring.Journal of clinical medicine · 2019Review
- Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: A prospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2019Article
- New Approaches in Hypertension Management: a Review of Current and Developing Technologies and Their Potential Impact on Hypertension Care.Current hypertension reports · 2019Review
- Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia.Pregnancy hypertension · 2019Review
- Risk factors of obstetric admissions to the intensive care unit: An 8-year retrospective study.Medicine · 2019Observational
- Development and evaluation of a novel Vital Signs Alert device for use in pregnancy in low-resource settings.BMJ innovations · 2018Article
- Blood pressure measurement in special populations and circumstances.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Innovations in vital signs measurement for the detection of hypertension and shock in pregnancy.Reproductive health · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo evaluate the association between blood pressure (BP) measurements and adverse outcomes in women with pre-eclampsia. STUDY
designA prospective cohort study of women with pre-eclampsia admitted to three South African tertiary facilities. BP was measured using the CRADLE Vital Signs Alert (VSA), incorporated with a traffic light early warning system; green: systolic BP <140 mmHg and diastolic BP <90 mmHg, yellow: systolic BP 140-159 and/or diastolic BP 90-109 mmHg (but neither is above the upper threshold), red: systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg.
main outcome measuresMaternal: death, eclampsia, stroke, kidney injury; process measures: magnesium sulfate use, Critical Care Unit (CCU) admission; perinatal: stillbirth, neonatal death, preterm delivery.
resultsOf 1547 women with pre-eclampsia (including 42 twin pregnancies), 33.0% of women triggered a red light on admission and 78.6% at their highest BP. Severe hypertension and adverse outcomes were common across yellow and red categories. Comparing admission red to yellow lights, there was a significant increase in kidney injury (OR 1.74, CI 1.31-2.33, trend test p = .003), magnesium sulfate use (OR 3.40, CI 2.24-5.18, p < .001) and CCU admission (OR 1.50, CI 1.18-1.91, p < .001), but not for maternal death, eclampsia, extended perinatal death or preterm delivery.
conclusionThe CRADLE VSA, with integrated traffic light early warning system, can identify women who are hypertensive, at increased risk of severe pre-eclampsia complications and in need of escalation of care. Women who triggered a red light were at increased risk of kidney injury, magnesium sulfate use and CCU admission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.