Evidence map›Paper›PMID 29175138›Full record

ArticleAnalytical biochemistry2018

Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H]

Adam V Wisnewski, Jian Liu, Carrie A Redlich, Ala F Nassar

Open access · bronzeAbstract read
In one paragraph

Article in Analytical biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adam V WisnewskiDepartment of Internal Medicine, Yale University, New Haven, CT 06520, United States. Electronic address: adam.wisnewski@yale.edu.
Jian LiuDepartment of Internal Medicine, Yale University, New Haven, CT 06520, United States.
Carrie A RedlichDepartment of Internal Medicine, Yale University, New Haven, CT 06520, United States.
Ala F NassarDepartment of Internal Medicine, Yale University, New Haven, CT 06520, United States.
Yale University · US

Funding

Deciphering Occupational Asthma Pathogenesis Caused by IsocyanateR01OH010941 · OH · YALE UNIVERSITY · PI WISNEWSKI, ADAM · 2016 to 2019
$2.2M
Biochemistry connecting glutathione and isocyanate asthmaR21OH010438 · OH · YALE UNIVERSITY · PI WISNEWSKI, ADAM · 2013 to 2014
$452k
ACL HHS R01OH010941NIOSH CDC HHS R01 OH010941NIOSH CDC HHS R21 OH010438
6 · The paper itself

Abstract

Hexamethylene diisocyanate (HDI) is an important industrial chemical that can cause asthma, however pathogenic mechanisms remain unclear. Upon entry into the respiratory tract, HDI's N=C=O groups may undergo nucleophilic addition (conjugate) to host molecules (e.g. proteins), or instead react with water (hydrolyze), releasing CO

Indexed as

Cells, CulturedChromatography, LiquidHumansIonsIsocyanatesMass SpectrometryMolecular StructurePolymerizationSolutions1,6-hexamethylene diisocyanateIonsIsocyanatesSolutionsDiamineDiisocyanateHexamethyleneHydrolyzePolymerize

Identifiers

PMID29175138
PMCPMC5826792
OpenAlexW2768787261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.