Evidence map›Paper›PMID 29175121›Full record

ArticleJournal of diabetes and its complications2018

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.

Surya N Mulukutla, Sarah A Tersey, Christiane S Hampe, Raghavendra G Mirmira, Ashok Balasubramanyam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. SYNDROMES OF KETOSIS-PRONE DIABETES.Transactions of the American Clinical and Climatological Association · 2019
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Surya N MulukutlaDepartment of Medicine, Section of Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX, USA.
Sarah A TerseyCenter for Diabetes and Metabolic Diseases, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Christiane S HampeDepartment of Medicine, University of Washington, Seattle, WA, USA.
Raghavendra G MirmiraCenter for Diabetes and Metabolic Diseases, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: rmirmira@iu.edu.
Ashok BalasubramanyamDepartment of Medicine, Section of Diabetes and Endocrinology, Baylor College of Medicine, Houston, TX, USA. Electronic address: ashokb@bcm.edu.
Baylor College of Medicine · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversity of Washington · US

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Transcriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5M
ISLET CELL MEMBRANE ANTIBODIES IN DIABTESR01DK026190 · NIDDK · UNIVERSITY OF WASHINGTON · PI HAMPE, CHRISTIANE S · 1986 to 2016
$4.9M
Biomarkers Of Beta Cell Stress In Type 1 Diabetes (BetaMarker)UC4DK104166 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EIZIRIK, DECIO LAKS, EVANS-MOLINA, CARMELLA · 2014 to 2014
$2.4M
NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK026190NIDDK NIH HHS R01 DK060581NIDDK NIH HHS UC4 DK104166
6 · The paper itself

Abstract

A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.

Indexed as

DNA MethylationAdultBiomarkersCohort StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisDNAFemaleHumansInsulinInsulin-Secreting CellsMaleUp-RegulationBiomarkersDNAInsulinBeta cell deathDiabetic KetoacidosisInsulin DNAIslet dysfunctionKetosis prone diabetes

Identifiers

PMID29175121
PMCPMC6170161
OpenAlexW2766103304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.