Evidence map›Paper›PMID 29174767›Full record

ArticleJournal of molecular and cellular cardiology2018

Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes.

Xi Chen, Craig Weber, Emily T Farrell, Francisco J Alvarado, Yan-Ting Zhao, Ana M Gómez, Héctor H Valdivia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Loss of phospholamban phosphorylation blunts CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Unbalance Between Sarcoplasmic Reticulum CaFrontiers in physiology · 2019
    Review
  13. Sorcin: a novel potential target in therapies of cancers.Cancer management and research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Xi ChenCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: xichenum@umich.edu.
Craig WeberDepartment of Physiology, University of Arizona College of Medicine, Tucson, AR 85724, USA.
Emily T FarrellDepartment of Pediatrics, Division of Cardiology, University of Wisconsin, Madison, WI 53705, USA.
Francisco J AlvaradoCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yan-Ting ZhaoCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Ana M GómezUMR-S 1180, Faculté de Pharmacie, Université Paris-Sud, Chatenay-Malabry 92296, France.
Héctor H ValdiviaCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: hvaldiv@umich.edu.
University of Michigan–Ann Arbor · USInstitut Galien Paris-Saclay · FRUniversity of Arizona · USUniversity of Wisconsin–Madison · US

Funding

Ryanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0M
Natural Agonists of Ryanodine Receptors: Structure-function Relationship and Antiarrhythmic PropertiesR01HL134344 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2017 to 2020
$1.9M
Cytosolic Calcium Sweeper in Cardiac MyocytesR01HL120108 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL120108NHLBI NIH HHS R01 HL134344
6 · The paper itself

Abstract

Sorcin, a penta-EF hand Ca

Indexed as

Gene DeletionAction PotentialsAnimalsArrhythmias, CardiacCalciumCalcium-Binding ProteinsCalcium Channels, L-TypeDeath, Sudden, CardiacElectrocardiographyHeart VentriclesIsoproterenolMice, KnockoutMyocytes, CardiacReceptors, Adrenergic, betaSarcoplasmic ReticulumSodium-Calcium ExchangerCalciumCalcium-Binding ProteinsCalcium Channels, L-TypeIsoproterenolReceptors, Adrenergic, betaSodium-Calcium ExchangerSri protein, mouseCardiac ventricular arrhythmiasL-type Ca(2+) channelRyanodine receptorsSodium-calcium exchangerSorcinVentricular myocytes

Identifiers

PMID29174767
PMCPMC5800963
OpenAlexW2769834075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.