Evidence map›Paper›PMID 29174583›Full record

ArticleBrazilian journal of otorhinolaryngology

The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats.

Doğukan Özdemir, Abdulkadir Özgür, Yıldıray Kalkan, Suat Terzi, Levent Tümkaya, Adnan Yılmaz, Metin Çeliker, Engin Dursun

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Doğukan ÖzdemirUniversity of Health Sciences, Samsun Health Practices and Research Center, Department of Otorhinolaryngology, Samsun, Turkey.
Abdulkadir ÖzgürUniversity of Health Sciences, Samsun Health Practices and Research Center, Department of Otorhinolaryngology, Samsun, Turkey. Electronic address: akozgur53@gmail.com.
Yıldıray KalkanRecep Tayyip Erdogan University, Medical Faculty, Department of Histology and Embryology, Rize, Turkey.
Suat TerziRecep Tayyip Erdogan University, Medical Faculty, Department of Otorhinolaryngology, Rize, Turkey.
Levent TümkayaRecep Tayyip Erdogan University, Medical Faculty, Department of Histology and Embryology, Rize, Turkey.
Adnan YılmazRecep Tayyip Erdogan University, Medical Faculty, Department of Biochemistry, Rize, Turkey.
Metin ÇelikerRecep Tayyip Erdogan University, Medical Faculty, Department of Otorhinolaryngology, Rize, Turkey.
Engin DursunRecep Tayyip Erdogan University, Medical Faculty, Department of Otorhinolaryngology, Rize, Turkey.
Recep Tayyip Erdoğan University · TRSağlık Bilimleri Üniversitesi · TRSamsun University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, restricts its usage.

objectiveWe aimed to investigate the protective effects of whortleberry extract against cisplatin-induced ototoxicity by evaluating hearing and histopathological cochlear damage and by measuring the biochemical parameters affected byoxidative stress.

methodsForty-eight male rats were included in the study after performing Distortion Product Otoacoustic Emission test to confirm that their hearing levels were normal. The rats were randomly divided into six groups: the control group, the sham group, and, which received only whortleberry extract, only cisplatin, cisplatin+100mg whortleberry extract, cisplatin+200mg whortleberry extract, respectively. Audiologic investigation was performed by performing the Distortion Product Otoacoustic Emission test at the beginning and at the eighth day of the study. Cardiac blood samples were collected for biochemical analysis, and the rats were sacrificed to obtain cochlear histopathological specimens on the eighth day.

resultsThe results revealed that whortleberry protects hearing against cisplatin-induced ototoxicity independent of the dose. However, high doses of whortleberry extract are needed to prevent histopathological degeneration and oxidative stress.

conclusionThe results obtained in this study show that whortleberry extract has a protective effect against cisplatin-induced ototoxicity.

Indexed as

Acoustic StimulationAnimalsAnthocyaninsAntineoplastic AgentsAntioxidantsCisplatinCochleaHearingMaleOtoacoustic Emissions, SpontaneousOxidative StressPlant ExtractsProtective AgentsRandom AllocationRats, WistarReference ValuesAnthocyaninsAntineoplastic AgentsAntioxidantsCisplatinPlant ExtractsProtective AgentsVaccinium myrtillus extractCisplatinCisplatinaExtrato de uva-do-monteOtotoxicidadeOtotoxicityWhorleberry extract

Identifiers

PMID29174583
PMCPMC9442816
OpenAlexW2767224331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.