Evidence map›Paper›PMID 29174490›Full record

ArticleThe American journal of cardiology2018

Risk of Cardiac Events Associated With Antidepressant Therapy in Patients With Long QT Syndrome.

Meng Wang, Barbara Szepietowska, Bronislava Polonsky, Scott McNitt, Arthur J Moss, Wojciech Zareba, David S Auerbach

Abstract read
In one paragraph

Article in The American journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Meng WangDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York.
Barbara SzepietowskaDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Bronislava PolonskyDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Scott McNittDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Arthur J MossDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Wojciech ZarebaDepartment of Medicine, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
David S AuerbachDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York; Department of Pharmacology & Physiology, University of Rochester Medical Center, Rochester, New York. Electronic address: david_auerbach@urmc.rochester.edu.
University of Rochester Medical Center · US

Funding

LONG QT SYNDROME--POPULATION, GENETIC, &CARDIAC STUDIESR01HL033843 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1985 to 2011
$5.9M
Institutional Career Development CoreKL2TR001999 · NCATS · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2016 to 2024
$5.2M
Clinical and Basic Science Studies in Long QT Syndrome Type 3R01HL123483 · NHLBI · UNIVERSITY OF ROCHESTER · PI KASS, ROBERT S, ZAREBA, WOJCIECH · 2014 to 2018
$3.7M
The Administrative Core of the Center of SUDEP ResearchU01NS090405 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LHATOO, SAMDEN, NOEBELS, JEFFREY · 2014 to 2018
$3.2M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
LONG QT SYNDROME--GENETIC STUDIESR01HL051618 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1993 to 2002
$1.2M
NCATS NIH HHS KL2 TR000095NCATS NIH HHS KL2 TR001999NHLBI NIH HHS R01 HL033843NHLBI NIH HHS R01 HL051618NHLBI NIH HHS R01 HL123483NINDS NIH HHS U01 NS090405
6 · The paper itself

Abstract

Patients with long QT syndrome (LQTS) are at a high risk of cardiac events. Many patients with LQTS are treated with antidepressant drugs (ADs). We investigated the LQTS genotype-specific risk of recurrent cardiac arrhythmic events (CAEs) associated with AD therapy. The study included 59 LQT1 and 72 LQT2 patients from the Rochester-based LQTS Registry with corrected QT (QT

Indexed as

Adrenergic beta-AntagonistsAdultAgedAntidepressive AgentsArrhythmias, CardiacDeath, Sudden, CardiacElectrocardiographyFemaleGenotypeHeart ArrestHumansLong QT SyndromeMaleMiddle AgedProportional Hazards ModelsRisk FactorsAdrenergic beta-AntagonistsAntidepressive Agents

Identifiers

PMID29174490
PMCPMC5742310
OpenAlexW2767749819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.