ArticleThe Journal of arthroplasty2018
Hypothyroidism Increases 90-Day Complications and Costs Following Primary Total Knee Arthroplasty.
Article in The Journal of arthroplasty, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Hypothyroidism is associated with higher healthcare utilisation and higher need for blood transfusion after primary total knee arthroplasty (TKA) in patients with osteoarthritis: A National Inpatient Sample analysis.Journal of experimental orthopaedics · 2026Article
- Trends and impact of comorbidities on Guyon's Canal release for the treatment of Guyon's Canal syndrome: A decade long nationwide analysis.Journal of orthopaedics · 2024Article
- Cardiovascular Disease in Total Knee Arthroplasty: An Analysis of Hospital Outcomes, Complications, and Mortality.Clinics in orthopedic surgery · 2024Article
- Preoperative Risk Factors for Periprosthetic Joint Infection: A Narrative Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Complications and hospitalization costs in patients with hypothyroidism following total hip arthroplasty.Journal of orthopaedic surgery and research · 2023Article
- Is thyroid disease associated with post-operative complications after total joint arthroplasty? A systematic review of the literature.EFORT open reviews · 2023Review
- Hypothyroidism and Spine Surgery: a Review of Current Findings.Current reviews in musculoskeletal medicine · 2023Review
- Bacteremia in Patients Undergoing Debridement, Antibiotics, and Implant Retention Leads to Increased Reinfections and Costs.Arthroplasty today · 2022Article
- Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study.Journal of clinical medicine · 2022Article
- Thyroid-stimulating hormone (TSH) is associated with 30-day mortality in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Incidence and Risk Factors of In-Hospital Prosthesis-Related Complications Following Total Knee Arthroplasty: A Retrospective Nationwide Inpatient Sample Database Study.Orthopaedic surgery · 2021Article
- Dermatomyositis and polymyositis in total hip arthroplasty.World journal of orthopedics · 2021Article
- Subclinical Hypothyroidism Affects Postoperative Outcome of Patients Undergoing Total Knee Arthroplasty.Orthopaedic surgery · 2021Article
- Musculoskeletal Manifestations in Sjogren's Syndrome: An Orthopedic Point of View.Journal of clinical medicine · 2021Review
- Identifying Risk Factors Associated With Postoperative Infection Following Elective Lower-Extremity Total Joint Arthroplasty.The Permanente journal · 2020Review
- Incidence and risk factors of in-hospital prosthesis-related complications following total hip arthroplasty: a retrospective Nationwide Inpatient Sample database study.International orthopaedics · 2020Article
- [Safety and effectiveness of total hip arthroplasty in patients with hypothyroidism].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Preoperative Potassium Iodide Treatment in Patients Undergoing Thyroidectomy for Graves' Disease-Perspective of a European High-Volume Center.World journal of surgery · 2020Article
- High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion.Global spine journal · 2019Article
- Risk stratification in primary total joint arthroplasty: the current state of knowledge.Arthroplasty today · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThyroid disease is common and often remains undetected in the US population. Thyroid hormone has an array of metabolic, immunologic, and musculoskeletal functions crucial to well-being. The influence of thyroid disease on perioperative outcomes following primary total knee arthroplasty (TKA) is poorly understood. We hypothesized that hypothyroidism was associated with a higher risk of postoperative complications and 90-day costs following primary TKA.
methodsThe Medicare standard analytical files were queried using International Classification of Disease codes between 2005 and 2014 to identify patients undergoing primary TKA. Patients with a diagnosis of hypothyroidism were matched by age and gender on a 1:1 ratio. Ninety-day postoperative complication rates, day of surgery, and 90-day global period charges and reimbursements were compared between matched cohorts.
resultsA total of 2,369,594 primary TKAs were identified between 2005 and 2014. After age and gender matching, each cohort consisted of 98,555 patients. Hypothyroidism was associated with greater odds of postoperative complications compared to matched controls (odds ratio 1.367, 95% confidence interval 1.322-1.413). The 90-day incidence of multiple postoperative medical and surgical complications, including periprosthetic joint infection, was higher among patients with hypothyroidism. Day of surgery and 90-day episode of care costs were significantly higher in the hypothyroidism cohort.
conclusionThis study demonstrated an increased risk of multiple postoperative complications and higher costs among patients with hypothyroidism following primary TKA. Surgeons should counsel patients on these findings and seek preoperative optimization strategies to reduce these risks and lower costs in this patient population.
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