Evidence map›Paper›PMID 29174333›Full record

ArticleCell stem cell2017

Injury Activates Transient Olfactory Stem Cell States with Diverse Lineage Capacities.

Levi Gadye, Diya Das, Michael A Sanchez, Kelly Street, Ariane Baudhuin, Allon Wagner, Michael B Cole, Yoon Gi Choi, Nir Yosef, Elizabeth Purdom and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 111 citations in OpenAlex.

  1. Trial
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  9. Review
  10. Article
  11. Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  12. Article
  13. Article
  14. Article
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  16. Article
  17. Review
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  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Levi GadyeHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Diya DasDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Berkeley Institute for Data Science, University of California, Berkeley, Berkeley, CA 94720, USA.
Michael A SanchezDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kelly StreetDivision of Biostatistics, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ariane BaudhuinDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Allon WagnerDepartment of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Michael B ColeDepartment of Physics, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yoon Gi ChoiQB3 Functional Genomics Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
Nir YosefDepartment of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Elizabeth PurdomDepartment of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Sandrine DudoitBerkeley Institute for Data Science, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Biostatistics, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Davide RissoDivision of Biostatistics, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY 10065, USA.
John NgaiHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; QB3 Functional Genomics Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: jngai@berkeley.edu.
Russell B FletcherDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
University of California, Berkeley · US

Funding

THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
Supplement for Programs of Gene Expression in Olfactory NeurogenesisR01DC007235 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUDOIT, SANDRINE · 2005 to 2022
$6.6M
Classification of Cortical Neurons by Single Cell TranscriptomicsU01MH105979 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2014 to 2016
$4.5M
Stem Cell Engineering Training ProgramT32GM098218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, SCHAFFER, DAVID V · 2011 to 2020
$1.8M
DEVELOPMENT OF GENOMIC INSTRUMENTATIONK22HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA IRVINE · PI BRODY, JAMES P · 2000 to 2004
$964k
Genome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623k
Illumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500k
Age-related changes in the neural stem cells of the olfactory epitheliumK01AG045344 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLETCHER, RUSSELL B · 2014 to 2016
$337k
NCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NHGRI NIH HHS K22 HG000047NHGRI NIH HHS T32 HG000047NIA NIH HHS K01 AG045344NIDCD NIH HHS R01 DC007235NIGMS NIH HHS T32 GM007232NIGMS NIH HHS T32 GM098218NIMH NIH HHS U01 MH105979
6 · The paper itself

Abstract

Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques, we assessed the transcriptional changes associated with stem cell self-renewal and differentiation and followed the maturation of stem cell-derived clones using sparse lineage tracing in the regenerating mouse olfactory epithelium. Following injury, quiescent olfactory stem cells rapidly shift to activated, transient states unique to regeneration and tailored to meet the demands of injury-induced repair, including barrier formation and proliferation. Multiple cell fates, including renewed stem cells and committed differentiating progenitors, are specified during this early window of activation. We further show that Sox2 is essential for cells to transition from the activated to neuronal progenitor states. Our study highlights strategies for stem cell-mediated regeneration that may be conserved in other adult stem cell niches.

Indexed as

Cell LineageAnimalsCell DifferentiationFemaleMaleMiceMice, Inbred C57BLMice, TransgenicOlfactory MucosaSOXB1 Transcription FactorsStem CellsSox2 protein, mouseSOXB1 Transcription Factorscell fatecell statelineagelineage tracingolfactoryregenerationscRNA-seqstem cells

Identifiers

PMID29174333
PMCPMC5728414
OpenAlexW2769220533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.