Evidence map›Paper›PMID 29174262›Full record

Observational studyIndian heart journal

Perioperative plasma mitochondrial DNA dynamics and correlation with inflammation during infantile cardiopulmonary bypass.

Fei Xu, Rui-Qi Liu, Rong Cao, Lang-Tao Guo, Ning Zhang, Ke Huang, Yu Cui, Wei-Na Li, Lei Li, Zheng-Hua Huang

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fei XuDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Rui-Qi LiuDepartment of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Rong CaoDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Lang-Tao GuoDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Ning ZhangDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Ke HuangDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Yu CuiDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Wei-Na LiDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Lei LiDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China.
Zheng-Hua HuangDepartment of Anesthesiology, Chengdu Women and Children's Central Hospital, Chongqing Medical University, Chengdu, Sichuan 610091, China. Electronic address: doctorxufei@gmail.com.
Chongqing Medical University · CNChengdu Women's and Children's Central Hospital · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNumerous studies in animals and humans have demonstrated that inflammatory mediators such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-8 play a role in cardiopulmonary bypass (CPB), which might affect surgical outcomes. Plasma mitochondrial DNA (mtDNA), a recently discovered pro-inflammatory agent, is released by cells upon insult. This study aimed to detect changes in plasma mtDNA levels at different time points after infantile CPB and explore its potential association with inflammatory mediators.

methodsIn the present study, we analyzed the perioperative plasma mtDNA and inflammatory cytokine levels of 48 infants undergoing ventricular septal defect closure. Blood samples were collected before aortic cross-clamping (T1), at the end of CPB (T2), and 6h (T3), 12h (T4), and 24h (T5) post-CPB. Reverse transcription-polymerase chain reaction and specific enzyme-linked immunosorbent assay were used to quantify the plasma mtDNA and inflammatory cytokines, respectively. Bivariate correlation analysis was used to determine the correlations between plasma mtDNA and inflammatory cytokines.

resultsPlasma mtDNA levels increased at T2 and peaked at T3. Significant positive correlations were found between peak plasma mtDNA (at T3) and several inflammatory biomarkers, including IL-6 (at T3) (r=0.62, P<0.001), IL-8 (at T2) (r=0.53, P<0.001), and TNF-α (at T3) (r=0.61, P<0.001).

conclusionHere we report that mtDNA may participate in a systemic inflammatory response to CPB.

Indexed as

BiomarkersCardiopulmonary BypassCytokinesDNA, MitochondrialFemaleHeart Septal Defects, VentricularHumansInfantInflammationIntraoperative PeriodMalePerioperative PeriodProspective StudiesReverse Transcriptase Polymerase Chain ReactionBiomarkersCytokinesDNA, MitochondrialCardiopulmonary bypassInfantsInflammatory responseInterleukin-6Interleukin-8Tumor necrosis factor-α

Identifiers

PMID29174262
PMCPMC5717290
OpenAlexW2600525718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.