ArticleAcademic radiology2018
Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI.
Article in Academic radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- [Bronchial asthma and bronchial hyperreactivity : Role of imaging].Radiologie (Heidelberg, Germany) · 2026Review
- Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage.Academic radiology · 2026Article
- Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease.Blood advances · 2025Article
- Disease Classification of Pulmonary Xenon Ventilation MRI Using Artificial Intelligence.Academic radiology · 2025Article
- Assessment of ventilation heterogeneity in severe asthma using phase-resolved functional lung magnetic resonance imaging.Physiological reports · 2025Article
- Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma.Immunological reviews · 2025Review
- A method for MRI-guided bronchoscopy to identify obstructed airway segments.Physiological reports · 2025Article
- Pulmonary MRI with hyperpolarized xenon-129 demonstrates novel alterations in gas transfer across the air-blood barrier in asthma.Medical physics · 2024Article
- Simultaneous quantification of hyperpolarized xenon-129 ventilation and gas exchange with multi-breath xenon-polarization transfer contrast (XTC) MRI.Magnetic resonance in medicine · 2023Article
- Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling.Advances in experimental medicine and biology · 2023Article
- Biologics and airway remodeling in severe asthma.Allergy · 2022Review
- Preclinical Four-Dimensional Functional Lung Imaging and Quantification of Regional Airflow: A New Standard in Lung Function Evaluation in Murine Models.American journal of respiratory cell and molecular biology · 2022Article
- Observational
- The emerging role of quantitative imaging in asthma.The British journal of radiology · 2022Article
- Lung MRI with hyperpolarised gases: current & future clinical perspectives.The British journal of radiology · 2022Review
- Xenon ventilation MRI in difficult asthma: initial experience in a clinical setting.ERJ open research · 2021Article
- Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency.The Journal of allergy and clinical immunology · 2020Article
- Generalized Linear Binning to Compare HyperpolarizedAcademic radiology · 2020Article
- The Hidden Burden of Severe Asthma: From Patient Perspective to New Opportunities for Clinicians.Journal of clinical medicine · 2020Review
- Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients.Pediatric radiology · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesTo determine lobar ventilation patterns in asthmatic lungs with hyperpolarized MATERIALS AND
methodsEighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma) underwent HP
resultsIn mild-to-moderate asthma, the RML and RUL showed significantly greater VDP than the two lower lobes (RLL and LLL) (P ≤ .047). In severe asthma, the pattern was more variable with the VDP in the RUL significantly greater than in the RLL (P = .026). In both asthma groups, the lower lobes (RLL and LLL) showed significantly higher high ventilation percent and Hs compared to the three upper lobes (all P ≤ .015).
conclusionsIn asthma, the RML and RUL showed greater ventilation abnormalities, and the RLL and LLL were more highly ventilated with greater local heterogeneity. These findings may facilitate guided bronchoscopic sampling and localized airway treatment in future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.