Trial reportThe Journal of pediatrics2018
Laryngeal Mask Airway for Surfactant Administration in Neonates: A Randomized, Controlled Trial.
Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Laryngeal Mask Airway (LMA) for Surfactant Administration in Neonates
A Clinical Trial Comparing Surfactant Administration Through Supraglottic Airway or Thin Catheter for Preterm Infants
Who cites it
53 citing papers in PubMed, 10 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2025.Neonatology · 2026Guideline
- Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Eligible Infants Included in Neonatal Clinical Trials and Reasons for Noninclusion: A Systematic Review.JAMA network open · 2024Pooled it
- Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2024Pooled it
- Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials: A Systematic Review.JAMA network open · 2023Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Sustained inflations and avoiding mechanical ventilation to prevent death or bronchopulmonary dysplasia: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Laryngeal mask airway versus bag-mask ventilation or endotracheal intubation for neonatal resuscitation.The Cochrane database of systematic reviews · 2018Pooled it
- Comparison of laryngeal mask airway and endotracheal tube placement in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Predictors of successful treatment of respiratory distress with aerosolized calfactant.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Nasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2019Trial
- Effect of sustained inflation on pharmacokinetics and pharmacodynamics of endotracheal and supraglottic airway epinephrine in a neonatal piglet model.Pediatric research · 2026Article
- Fiberscope-Assisted Surfactant Therapy (FAST) in Neonatal Respiratory Distress Syndrome: Four-Year Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study.Pediatric research · 2026Article
- Non-Invasive Surfactant Administration in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Prophylactic surfactant therapy in the era of less invasive surfactant delivery.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if preterm infants with moderate respiratory distress syndrome on continuous positive airway pressure (CPAP) who received surfactant via a laryngeal mask airway (LMA) would have a decreased rate of intubation and mechanical ventilation compared with those on CPAP who did not receive surfactant. STUDY
designIn this prospective, multicenter, randomized controlled trial, 103 premature infants 28
resultsSurfactant administration through an LMA (n = 50) significantly decreased the rate of intubation and mechanical ventilation compared with controls (n = 53): 38% vs 64%, respectively, OR 0.30 (95% CI 0.13, 0.70), P = .006, number needed to treat: 4). There were no serious adverse events associated with placement of the LMA or surfactant administration.
conclusionsIn premature neonates with moderate respiratory distress syndrome, surfactant administered through an LMA decreased the rate of intubation and mechanical ventilation. This intervention may have significant impact on clinical care in both high and low resource settings.
trial registrationClinicalTrials.gov: NCT01116921.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.