Evidence map›Paper›PMID 29173896›Full record

ArticleStem cell reports2017

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery.

Ayden Gouveia, Matthew Seegobin, Timal S Kannangara, Ling He, Fredric Wondisford, Cesar H Comin, Luciano da F Costa, Jean-Claude Béïque, Diane C Lagace, Baptiste Lacoste and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  9. Review
  10. Key Phytochemicals and Biological Functions ofFrontiers in pharmacology · 2021
    Article
  11. Article
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  16. Article
  17. Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019
    Review
  18. Review
  19. Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  20. Pericyte Plasticity in the Brain.Neuroscience bulletin · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Ayden GouveiaRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Matthew SeegobinRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Timal S KannangaraDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.
Ling HeDepartment of Pediatrics and Medicine, Johns Hopkins Medical School, Baltimore, MD, USA.
Fredric WondisfordDepartment of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Cesar H CominDepartment of Computer Science, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
Luciano da F CostaSão Carlos Institute of Physics, University of São Paulo, PO Box 369, São Carlos, São Paulo 13560-970, Brazil.
Jean-Claude BéïqueDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.
Diane C LagaceDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.
Baptiste LacosteDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.
Jing WangRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada. Electronic address: jiwang@ohri.ca.
Heart and Stroke Foundation · CAUniversity of Ottawa · CAuOttawa Brain and Mind Research InstituteJohns Hopkins University · USOttawa Hospital Research InstituteRutgers, The State University of New Jersey · USUniversidade de São Paulo · BRUniversidade Federal de São Carlos · BR

Funding

Transcriptional coactivators and hepatic glucose productionR01DK063349 · NIDDK · UNIVERSITY OF CHICAGO · PI WONDISFORD, FREDRIC E. · 2002 to 2017
$5.0M
Activation of the cAMP-PKA pathway antagonizes metformin actionR01DK107641 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HE, LING · 2016 to 2020
$1.8M
CIHR MOP142420CIHR MOP378718NIDDK NIH HHS R01 DK063349NIDDK NIH HHS R01 DK107641
6 · The paper itself

Abstract

Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage releases micro-environmental cues, we examined the role of a signaling-induced epigenetic pathway, an atypical protein kinase C (aPKC)-mediated phosphorylation of CREB-binding protein (CBP), in post-stroke neurovascular remodeling. Using a knockin mouse strain (CbpS436A) where the aPKC-CBP pathway was defective, we show that disruption of the aPKC-CBP pathway in a murine focal ischemic stroke model increases the reprogramming efficiency of ischemia-activated pericytes (i-pericytes) to neural precursors. As a consequence of enhanced cellular reprogramming, CbpS436A mice show an increased transient population of locally derived neural precursors after stroke, while displaying a reduced number of i-pericytes, impaired vascular remodeling, and perturbed motor recovery during the chronic phase of stroke. Together, this study elucidates the role of the aPKC-CBP pathway in modulating neurovascular remodeling and functional recovery following focal ischemic stroke.

Indexed as

AnimalsBrain IschemiaCellular ReprogrammingCREB-Binding ProteinMiceNeurogenesisPericytesPhosphorylationProtein Kinase CRecovery of FunctionSignal TransductionStrokeStroke RehabilitationVascular RemodelingCREB-Binding ProteinCrebbp protein, mousePKC-3 proteinProtein Kinase CaPKC-CBP pathwaycellular reprogrammingischemic strokeneural precursorspericytevascular remodeling

Identifiers

PMID29173896
PMCPMC5785704
OpenAlexW2769721651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.