ArticleStem cell reports2017
Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.
Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- KRT5Stem cell research & therapy · 2025Article
- PPARγ promotes urothelial remodeling during urinary tract obstruction.Experimental & molecular medicine · 2025Article
- Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium.American journal of physiology. Renal physiology · 2024Article
- The urothelium: a multi-faceted barrier against a harsh environment.Mucosal immunology · 2022Review
- Arid1a regulates bladder urothelium formation and maintenance.Developmental biology · 2022Article
- Development, regeneration and tumorigenesis of the urothelium.Development (Cambridge, England) · 2022Review
- Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma.Cancers · 2021Review
- Pparg signaling controls bladder cancer subtype and immune exclusion.Nature communications · 2021Article
- Procyanidins-crosslinked small intestine submucosa: A bladder patch promotes smooth muscle regeneration and bladder function restoration in a rabbit model.Bioactive materials · 2021Article
- Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury.Cell death & disease · 2021Article
- Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics.Cell proliferation · 2021Article
- Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts.Scientific reports · 2021Article
- The Urothelium: Life in a Liquid Environment.Physiological reviews · 2020Review
- Keratinocyte Growth Factor Reduces Injury and Leads to Early Recovery from Cyclophosphamide Bladder Injury.The American journal of pathology · 2020Article
- Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication.Cell reports · 2018Article
- Tissue engineering in pediatric urology - a critical appraisal.Innovative surgical sciences · 2018Review
- Tissue Engineering and Stem Cell Therapy in Pediatric Urology.Journal of Indian Association of Pediatric SurgeonsReview
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The bladder urothelium functions as a urine-blood barrier and consists of basal, intermediate, and superficial cell populations. Reconstructive procedures such as augmentation cystoplasty and focal mucosal resection involve localized surgical damage to the bladder wall whereby focal segments of the urothelium and underlying submucosa are respectively removed or replaced and regeneration ensues. We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites. Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues. These results highlight the diversity of urothelial regenerative responses to surgical injury and may lead to advancements in bladder tissue engineering approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.