ArticleDevelopmental cell2017
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 56 citations in OpenAlex.
- Cell-autonomous control coupled with tissue context regulates the cessation of migration at the site of organ development.Development (Cambridge, England) · 2026Article
- Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.Cell reports methods · 2026Article
- Bleb expansion requires transient membrane invaginations that sequester curvature-preferring proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plasma membrane invaginations and their diverse cellular functions.BMC biology · 2026Review
- Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026Review
- Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Confinement by Liquid-Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb-Based Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cellular mechanisms of traumatic brain injury.npj biological physics and mechanics · 2025Review
- Centrosome-organized plasma membrane infoldings linked to growth of a cortical actin domain.The Journal of cell biology · 2024Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Changes in cell surface excess are coordinated with protrusion dynamics during 3D motility.Biophysical journal · 2023Article
- Consumption of a polarized membrane reservoir drives asymmetric membrane expansion during the unequal divisions of neural stem cells.Developmental cell · 2023Article
- Model of inverse bleb growth explains giant vacuole dynamics during cell mechanoadaptation.PNAS nexus · 2023Article
- Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo.Development (Cambridge, England) · 2023Article
- Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy.Histochemistry and cell biology · 2022Article
- Interplay between mechanics and signalling in regulating cell fate.Nature reviews. Molecular cell biology · 2022Review
- Blebs-Formation, Regulation, Positioning, and Role in Amoeboid Cell Migration.Frontiers in cell and developmental biology · 2022Review
- How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers.Frontiers in pharmacology · 2022Review
- Proper Balance of Small GTPaseInternational journal of molecular sciences · 2021Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Cell migration is essential for morphogenesis, organ formation, and homeostasis, with relevance for clinical conditions. The migration of primordial germ cells (PGCs) is a useful model for studying this process in the context of the developing embryo. Zebrafish PGC migration depends on the formation of cellular protrusions in form of blebs, a type of protrusion found in various cell types. Here we report on the mechanisms allowing the inflation of the membrane during bleb formation. We show that the rapid expansion of the protrusion depends on membrane invaginations that are localized preferentially at the cell front. The formation of these invaginations requires the function of Cdc42, and their unfolding allows bleb inflation and dynamic cell-shape changes performed by migrating cells. Inhibiting the formation and release of the invaginations strongly interfered with bleb formation, cell motility, and the ability of the cells to reach their target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.