Evidence map›Paper›PMID 29173743›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017

Clinical Correlates of Carbon Dioxide Hypersensitivity in Children.

Lance M Rappaport, Christina Sheerin, Dever M Carney, Kenneth E Towbin, Ellen Leibenluft, Daniel S Pine, Melissa A Brotman, Roxann Roberson-Nay, John M Hettema

Open access · greenAbstract readTwin Study
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates.Journal of the American Academy of Child and Adolescent Psychiatry · 2018
    Article
  6. Differential Associations of Distress Tolerance and Anxiety Sensitivity With Adolescent Internalizing Psychopathology.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lance M RappaportVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond. Electronic address: Lance.Rappaport@vcuhealth.org.
Christina SheerinVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
Dever M CarneyVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
Kenneth E TowbinNational Institute of Mental Health, Bethesda, MD.
Ellen LeibenluftNational Institute of Mental Health, Bethesda, MD.
Daniel S PineNational Institute of Mental Health, Bethesda, MD.
Melissa A BrotmanNational Institute of Mental Health, Bethesda, MD.
Roxann Roberson-NayVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
John M HettemaVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.
Virginia Commonwealth University · USNational Institute of Mental Health · US

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
A Twin Study of Negative Valence Emotional ConstructsR01MH098055 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HETTEMA, JOHN M · 2012 to 2014
$1.6M
Intramural NIH HHS ZIA MH002781NCATS NIH HHS UL1 TR000058NIMH NIH HHS R01 MH098055NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

objectiveHypersensitivity to carbon dioxide (CO

methodHealthy children from a community twin sample (N = 538; age 9-13 years) rated anxious distress every 2 minutes while breathing air enriched to 7.5% CO

resultsAlthough all participants reported increased distress during the task, interindividual heterogeneity in distress indexed 3 underlying classes: a consistently low class ("low"), a consistently high class ("high"), and participants who demonstrated markedly increased acute distress ("acute"). Compared to the low class, the high class reported greater internalizing psychopathology, whereas membership in the acute class was associated with experiencing a panic-like event during the task.

conclusionAs in older individuals, 3 distinct trajectories emerged to capture interindividual heterogeneity in children's distress during the CO

Indexed as

AdolescentAnxietyAnxiety DisordersCarbon DioxideChildFemaleHumansHypersensitivityIndividualityMaleModels, PsychologicalModels, StatisticalPsychiatric Status Rating ScalesRisk AssessmentRisk FactorsSensitivity and SpecificityCarbon Dioxideanxietyanxiety disorderscarbon dioxide hypersensitivitylatent growth mixture modeling

Identifiers

PMID29173743
PMCPMC5762134
OpenAlexW2759369620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.