Evidence map›Paper›PMID 29173741›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017

Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts.

Holly C Wilcox, Janice M Fullerton, Anne L Glowinski, Kelly Benke, Masoud Kamali, Leslie A Hulvershorn, Emma K Stapp, Howard J Edenberg, Gloria M P Roberts, Neera Ghaziuddin and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 2 countries.

Holly C WilcoxJohns Hopkins University, Baltimore, MD. Electronic address: hwilcox1@jhmi.edu.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales (NSW), Australia; University of New South Wales, Sydney.
Anne L GlowinskiWashington University School of Medicine, St. Louis.
Kelly BenkeJohns Hopkins University, Baltimore, MD.
Masoud KamaliMassachusetts General Hospital and Harvard University, Boston.
Leslie A HulvershornIndiana University School of Medicine, Indianapolis.
Emma K StappJohns Hopkins University, Baltimore, MD.
Howard J EdenbergIndiana University School of Medicine, Indianapolis.
Gloria M P RobertsUniversity of New South Wales, Sydney; Black Dog Institute, Sydney.
Neera GhaziuddinUniversity of Michigan, Ann Arbor.
Carrie FisherIndiana University School of Medicine, Indianapolis.
Christine BruckschUniversity of Michigan, Ann Arbor.
Andrew FranklandUniversity of New South Wales, Sydney; Black Dog Institute, Sydney.
Claudio TomaNeuroscience Research Australia, Sydney, New South Wales (NSW), Australia; University of New South Wales, Sydney.
Alex D ShawNeuroscience Research Australia, Sydney, New South Wales (NSW), Australia; University of New South Wales, Sydney.
Elizabeth KastelicJohns Hopkins University, Baltimore, MD.
Leslie MillerJohns Hopkins University, Baltimore, MD.
Melvin G McInnisUniversity of Michigan, Ann Arbor.
Philip B MitchellUniversity of New South Wales, Sydney; Black Dog Institute, Sydney.
John I NurnbergerIndiana University School of Medicine, Indianapolis; Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis.
Johns Hopkins University · USUNSW Sydney · AUIndiana University – Purdue University Indianapolis · USUniversity of Michigan–Ann Arbor · USBlack Dog Institute · AUIndiana University School of MedicineMassachusetts General Hospital · USNeuroscience Research Australia · AUWashington University in St. Louis · US

Funding

PSYCHIATRIC EPIDEMIOLOGY TRAINING PROGRAMT32MH014592 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HEATHER E VOLK, Peter P. Zandi · 1985 to 2026
$8.5M
Adolescents at High Risk for Familial Bipolar DisorderR01MH068009 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 2005 to 2009
$1.7M
Adolescents at High Risk for Familial Bipolar Disorder.R01MH068006 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCINNIS, MELVIN G · 2005 to 2009
$1.4M
Adolescents at High Risk For Familial Bipolar DisorderR01MH073151 · NIMH · WASHINGTON UNIVERSITY · PI GLOWINSKI, ANNE L · 2005 to 2009
$1.3M
NIMH NIH HHS R01 MH068006NIMH NIH HHS R01 MH068009NIMH NIH HHS R01 MH073151NIMH NIH HHS T32 MH014592
6 · The paper itself

Abstract

objectiveBipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk score in relation to suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) in adolescent and young adult offspring and relatives of persons with BD (BD-relatives) compared with adolescent and young adult offspring of individuals without psychiatric disorders (controls).

methodData were collected from 4 sites in the United States and 1 site in Australia from 2006 through 2012. Generalized estimating equation models were used to compare rates of ideation, attempts, and NSSI between BD-relatives (n = 307) and controls (n = 166) and to determine the contribution of demographic factors, traumatic stress exposure, lifetime mood or substance (alcohol/drug) use disorders, and BD polygenic risk score.

resultsAfter adjusting for demographic characteristics and mood and substance use disorders, BD-relatives were at increased risk for suicidal ideation and attempts but not for NSSI. Independent of BD-relative versus control status, demographic factors, or mood and substance use disorders, exposure to trauma within the past year (including bullying, sexual abuse, and domestic violence) was associated with suicide attempts (p = .014), and BD polygenic risk score was marginally associated with attempts (p = .061). Importantly, the interaction between BD polygenic risk score and traumatic event exposures was significantly associated with attempts, independent of demographics, relative versus control status, and mood and substance use disorders (p = .041).

conclusionBD-relatives are at increased risk for suicide attempts and ideation, especially if they are exposed to trauma and have evidence of increased genetic vulnerability.

Indexed as

Genetic Predisposition to DiseaseAdolescentBipolar DisorderCase-Control StudiesChildFemaleFollow-Up StudiesHumansMaleModels, StatisticalPolymorphism, Single NucleotidePsychiatric Status Rating ScalesPsychological TraumaRetrospective StudiesRisk AssessmentRisk Factorsattemptedbipolar disorderpolygenic riskpopulations at risksuicidetraumatic stress

Identifiers

PMID29173741
PMCPMC5797709
OpenAlexW2762641676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.