Evidence map›Paper›PMID 29173737›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2017

Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial.

Tara S Peris, Michelle S Rozenman, Catherine A Sugar, James T McCracken, John Piacentini

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01409642 (Pilot Feasibility Trial of Positive Family Interaction Therapy), which is not on this map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01409642 nacompletednot on this map

Pilot Feasibility Trial of Positive Family Interaction Therapy

TypeinterventionalSponsorUniversity of California, Los AngelesRan2008 to 2016Enrolled62ConditionsObsessive-Compulsive DisorderArmsIndividual Child CBT, Positive Family Interaction Therapy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  18. Parent-Only Treatment for Child Anxiety.Advances in psychiatry and behavioral health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tara S PerisUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles. Electronic address: tperis@mednet.ucla.edu.
Michelle S RozenmanUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles.
Catherine A SugarUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles; Fielding School of Public Health, UCLA.
James T McCrackenUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles.
John PiacentiniUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles.
Fielding Graduate University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Family Focused Intervention for Pediatric Obsessive Compulsive DisorderK23MH085058 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PERIS, TARA S · 2009 to 2013
$835k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIMH NIH HHS K23 MH085058
6 · The paper itself

Abstract

objectiveAlthough evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning.

methodParticipants were 62 youngsters aged 8 to 17 years (mean age = 12.71 years; 57% male; 65% white) with a primary diagnosis of OCD and at least 2 indicators of poor family functioning. They were randomized to receive 12 sessions of individual child cognitive-behavioral therapy (CBT) plus weekly parent psychoeducation and session review (standard treatment [ST]) or the same 12 child sessions plus 6 sessions of family therapy aimed at improving OCD-related emotion regulation and problem solving (positive family interaction therapy [PFIT]). Blinded raters evaluated outcomes and tracked responders to 3-month follow-up.

resultsCompared to ST, PFIT demonstrated better overall response rates on the Clinician Global Impression-Improvement scale (CGI-I; 68% versus 40%, p = .03, φ = 0.28) and rates of remission (58% PFIT versus 27% ST, p = .01, φ = 0.32). PFIT also produced significantly greater reductions in functional impairment, symptom accommodation, and family conflict, and improvements in family cohesion. As expected, these shifts in family functioning constitute an important treatment mechanism, with changes in accommodation mediating treatment response.

conclusionPFIT is efficacious for reducing OCD symptom severity and impairment and for improving family functioning. Findings are discussed in terms of personalized medicine and mechanisms of change in pediatric OCD treatment. Clinical trial registration information-Family Focused Treatment of Pediatric Obsessive Compulsive Disorder; http://clinicaltrials.gov/; NCT01409642.

Indexed as

AdolescentChildCognitive Behavioral TherapyCombined Modality TherapyFamily RelationsFamily TherapyFemaleFollow-Up StudiesHumansMaleObsessive-Compulsive DisorderParentsPsychiatric Status Rating ScalesSingle-Blind MethodTreatment OutcomeCBTexposurefamily treatmentpediatric OCD

Identifiers

PMID29173737
PMCPMC5875916
OpenAlexW2761835715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.