Evidence map›Paper›PMID 29173446›Full record

ArticleRespiratory medicine2017

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children.

Andrew Nicholson, Suzanne L Pollard, John J Lima, Karina M Romero, Carla Tarazona-Meza, Gary Malpartida-Guzmán, Edward Mougey, Nadia N Hansel, William Checkley, GASP Study Investigators

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Serum folate metabolites, asthma, and lung function in a nationwide US study.The Journal of allergy and clinical immunology · 2020
    Trial
  2. Review
  3. Review
  4. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Frontiers in immunology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Household food insecurity is associated with asthma control in Peruvian children living in a resource-poor setting.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Andrew NicholsonDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
Suzanne L PollardDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
John J LimaCenter for Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, FL, USA.
Karina M RomeroDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA; Biomedical Research Unit, A.B. PRISMA, Lima, Peru.
Carla Tarazona-MezaBiomedical Research Unit, A.B. PRISMA, Lima, Peru.
Gary Malpartida-GuzmánBiomedical Research Unit, A.B. PRISMA, Lima, Peru.
Edward MougeyCenter for Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, FL, USA.
Nadia N HanselDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.
William CheckleyDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA; Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA. Electronic address: wcheckl1@jhmi.edu.
GASP Study Investigators
Johns Hopkins University · USNemours Children's Health System · USPrisma · PE

Funding

Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Genetic Susceptibility to Asthma and IndoorAir Pollution in PeruR01ES018845 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2010 to 2014
$3.8M
Acute Lung Injury: Application of Novel Approaches to Longitudinal Data AnalysisR00HL096955 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM · 2011 to 2013
$723k
FIC NIH HHS R25 TW009340NHLBI NIH HHS R00 HL096955NIEHS NIH HHS R01 ES018845
6 · The paper itself

Abstract

backgroundThe relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common.

methodsAncillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6-9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up.

resultsA 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05-2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20-4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85-1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02-2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05-2.85).

conclusionsSerum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

Indexed as

AdolescentAsthmaCase-Control StudiesChildFemaleFolic AcidHumansHypersensitivity, ImmediateImmunoglobulin ELungMaleNitric OxidePeruRespiratory Function TestsSocial ClassFolic AcidImmunoglobulin ENitric OxideAsthmaAsthma controlAtopyFolatePediatric asthmaPeruvians

Identifiers

PMID29173446
PMCPMC5844363
OpenAlexW2766678514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.