Evidence map›Paper›PMID 29173323›Full record

ArticleThe Journal of pediatrics2017

Delayed Breastfeeding Initiation Is Associated with Infant Morbidity.

Emily R Smith, Lindsey M Locks, Karim P Manji, Christine M McDonald, Roland Kupka, Rodrick Kisenge, Said Aboud, Wafaie W Fawzi, Christopher P Duggan

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Emily R SmithDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: ers231@mail.harvard.edu.
Lindsey M LocksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Karim P ManjiDepartment of Pediatrics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Christine M McDonaldNutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA.
Roland KupkaDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Nutrition Section, United Nations Children's Fund (UNICEF) Headquarters, New York, NY.
Rodrick KisengeDepartment of Pediatrics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Christopher P DugganDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Muhimbili University of Health and Allied Sciences · TZBoston Children's Hospital · USHarvard University · USUnited Nations Children's Fund · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Trial of Vitamins among Children of HIV-infected MothersR01HD043688 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FAWZI, WAFAIE W · 2003 to 2007
$2.7M
A Trial of Zinc and Micronutrients in Tanzanian ChildrenR01HD048969 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI DUGGAN, CHRISTOPHER P · 2006 to 2010
$2.0M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24HD058795 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2010 to 2014
$956k
NICHD NIH HHS K24 HD058795NICHD NIH HHS R01 HD043688NICHD NIH HHS R01 HD048969NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

objectiveTo assess the relationship between breastfeeding initiation time and postneonatal mortality, morbidity, and growth through 24 months in a cohort of Tanzanian infants. STUDY

designWe included 4203 infants from 2 trials of micronutrient supplementation. We used Cox proportional hazards models or general estimating equations to estimate relative risks.

resultsA total of 13% of infants initiated breastfeeding >1 hour after birth (n = 536). There was no association between breastfeeding initiation time and risk of all-cause or cause-specific mortality, nor infant growth failure, from 6 weeks to 2 years of age. However, delayed breastfeeding was associated with an increased risk of several common infectious morbidities in early infancy, including upper respiratory infection symptoms and vomiting. Compared with those who initiated breastfeeding within the first hour of birth, delayed breastfeeding initiation was associated with an 11% increased risk of cough (relative risk 1.11, 95% CI 1.02-1.21) and a 48% increased risk of difficulty breathing (relative risk 1.48, 95% CI 1.09-2.01) during the first 6 months. Delayed initiation was associated with a greater risk of difficulty breathing from 6 to 12 months of age, but it was not associated with risk of any other morbidity during this time, nor any morbidity between 12 and 24 months.

conclusionDelayed breastfeeding initiation is associated with an increased risk of infant morbidity during the first 6 months of life. Early breastfeeding initiation, along with exclusive and prolonged breastfeeding, should be prioritized and promoted in efforts to improve child health.

Indexed as

Age FactorsBreast FeedingChild DevelopmentChild, PreschoolFemaleGrowth DisordersHumansInfantInfant, NewbornInfectionsLongitudinal StudiesMaleProportional Hazards ModelsProspective StudiesProtective FactorsRespiratory Tract Diseasesbreastfeeding initiationdiarrheainfant growthinfant mortalityrespiratory infectionsTanzania

Identifiers

PMID29173323
PMCPMC8011584
OpenAlexW2769836594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.