Observational studyThe Journal of pediatrics2017
Impact of the Neonatal Resuscitation Program-Recommended Low Oxygen Strategy on Outcomes of Infants Born Preterm.
Observational study in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 8. Neonatal resuscitation.Clinical and experimental emergency medicine · 2021Guideline
- Review
- Postnatal hypoxic preconditioning attenuates lung damage from hyperoxia in newborn mice.Pediatric research · 2025Article
- Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia.Antioxidants (Basel, Switzerland) · 2024Article
- Clinical Parameters in the First 5 Minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- The Respiratory Management of the Extreme Preterm in the Delivery Room.Children (Basel, Switzerland) · 2023Review
- Quality improvement for neonatal resuscitation and delivery room care.Seminars in perinatology · 2022Review
- Association of antenatal steroids with surfactant administration in moderate preterm infants born to women with diabetes mellitus and/or hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Executive Summary 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.Resuscitation · 2020Article
- Optimizing oxygen therapy for preterm infants at birth: Are we there yet?Seminars in fetal & neonatal medicine · 2020Review
- Oxygen Supplementation During Preterm Stabilization and the Relevance of the First 5 min After Birth.Frontiers in pediatrics · 2020Review
- Hemoglobin oxygen saturation targets in the neonatal intensive care unit: Is there a light at the end of the tunnel?Canadian journal of physiology and pharmacology · 2019Review
- Reduced rate of treated retinopathy of prematurity after implementing lower oxygen saturation targets.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Optimal Inspired Fraction of Oxygen in the Delivery Room for Preterm Infants.Children (Basel, Switzerland) · 2019Review
- Is There a "Right" Amount of Oxygen for Preterm Infant Stabilization at Birth?Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the impact of the Neonatal Resuscitation Program (NRP)-recommended low oxygen strategy (LOX) on neonatal morbidities, mortality, and neurodevelopmental outcomes in neonates born preterm. STUDY
designIn March 2011, Parkland Hospital changed from a high oxygen strategy (HOX) of resuscitation with initial 100% oxygen and targeting 85%-94% oxygen saturation for delivery room resuscitation to a LOX with initial 21% oxygen and titrating oxygen to meet NRP-recommended transitional target saturations. Neonates ≤28 weeks' gestational age born between August 2009 and April 2012 were identified. In this retrospective, observational study, neonates exposed to LOX vs HOX were compared for short-term morbidity, mortality, and long-term neurodevelopmental outcomes. Regression analysis was performed to control for confounding variables.
resultsOf 199 neonates, 110 were resuscitated with HOX and 89 with LOX. Compared with HOX, neonates exposed to LOX had lower oxygen exposure in the delivery room (5.2 ± 1.5 vs 7.8 ± 2.8 [∑FiO
conclusionThe NRP-recommended LOX strategy was associated with improved respiratory morbidities and neurodevelopmental outcomes with no increase in mortality. Prospective trials to confirm the optimal oxygen strategy for the resuscitation of neonates born preterm are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.