Evidence map›Paper›PMID 29173296›Full record

Observational studyThe Journal of pediatrics2017

Waist Circumference and Body Mass Index in Children with Chronic Kidney Disease and Metabolic, Cardiovascular, and Renal Outcomes.

Hiren P Patel, Jeffrey M Saland, Derek K Ng, Shuai Jiang, Bradley A Warady, Susan L Furth, Joseph T Flynn

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Nutrition across the Entire Lifespan in CKD: From Childhood to Senescence.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. The Relationship Between Neighborhood Disadvantage and Kidney Disease Progression in the Chronic Kidney Disease in Children (CKiD) Cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Observational
  8. Review
  9. Review
  10. Article
  11. Observational
  12. Can childhood obesity influence later chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2019
    Review
  13. Article
  14. Observational
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiren P PatelDepartment of Pediatrics, Ohio State University College of Medicine and Nationwide Children's Hospital, Columbus, OH. Electronic address: hiren.patel@nationwidechildrens.org.
Jeffrey M SalandDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Derek K NgDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Shuai JiangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Bradley A WaradyDivision of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, MO.
Susan L FurthDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Joseph T FlynnDepartment of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA.

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U01DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MUNOZ, ALVARO · 2003 to 2017
$17.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Central Biochemistry Laboratory of the CKiD ConsortiumU01DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2008 to 2017
$3.5M
Adiponectin and Cardiovascular Disease in the CKiD ChildrenR01DK076957 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MITSNEFES, MARK M. · 2007 to 2009
$779k
NICHD NIH HHS U54 HD079123NIDDK NIH HHS R01 DK076957NIDDK NIH HHS U01 DK066116NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U01 DK082194
6 · The paper itself

Abstract

objectiveTo describe the prevalence of obesity as estimated by waist circumference (WC) and body mass index (BMI) and compare associations of WC and BMI with indicators of metabolic, cardiovascular, and renal health in children with chronic kidney disease (CKD). STUDY

designCross-sectional analysis stratified by CKD etiology (nonglomerular or glomerular) of 737 subjects. The kappa statistic was used to assess agreement between the 2 measures of obesity. Linear regression models were performed using WC and BMI as separate independent variables. Dependent variables included lipid measures, insulin resistance, blood pressure, left ventricular mass index, proteinuria, and estimated glomerular filtration rate. Associations were scaled to SD and interpreted as the change in dependent variable associated with a 1-SD change in WC or BMI.

resultsThere was good agreement (kappa statistic = 0.68) between WC and BMI in identifying obesity. Approximately 10% of subjects had obesity by 1 measure but not the other. BMI was more strongly associated with estimated glomerular filtration rate than WC. BMI was more strongly associated with left ventricular mass index in the nonglomerular CKD group compared with WC, but both had significant associations. The associations between WC and BMI with the remainder of the dependent variables were not significantly different.

conclusionsMeasurement of WC added limited information to BMI in this cohort. Further longitudinal study is needed to determine how WC and BMI compare in predicting outcomes, particularly for children with CKD identified as having obesity by 1 measure but not the other.

Indexed as

Body Mass IndexWaist CircumferenceAdolescentCardiovascular DiseasesChildChild, PreschoolCross-Sectional StudiesFemaleHumansLinear ModelsMaleMetabolic SyndromeObesity, AbdominalPediatric ObesityPrevalenceRenal Insufficiency, Chronicblood pressuredyslipidemiametabolic syndromeobesitypediatric

Identifiers

PMID29173296
PMCPMC5728693

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.