Evidence map›Paper›PMID 29172838›Full record

ArticlePharmaceutical biology2017

In vitro schistosomicidal activity of the lignan (-)-6,6'-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni.

Thaís C Lima, Rodrigo Lucarini, Priscilla P Luz, Emerson H de Faria, Liziane Marçal, Lizandra G Magalhães, Fernanda R Badoco, Viviane R Esperandim, Eduardo F Molina, Rosangela S Laurentz and 4 more

Abstract read
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In one paragraph

Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thaís C Limaa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Rodrigo Lucarinia Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Priscilla P Luzb Departamento de Química-CCE , Universidade Federal do Espírito Santo (UFES) , Vitoria , Brazil.
Emerson H de Fariaa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Liziane Marçala Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Lizandra G Magalhãesa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Fernanda R Badocoa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Viviane R Esperandima Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Eduardo F Molinaa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Rosangela S Laurentzc Faculdade de Engenharia de Ilha Solteira , Universidade Estadual Paulista , Ilha Solteira , Brazil.
Regiane G Limac Faculdade de Engenharia de Ilha Solteira , Universidade Estadual Paulista , Ilha Solteira , Brazil.
Wilson R Cunhaa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.
Jairo K Bastosd School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.
Marcio L Andrade Silvaa Laboratório de Pesquisa em Microbiologia Aplicada, Núcleo de Ciências Exatas e Tecnológicas , Universidade de Franca , Franca , Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context(-)-6,6'-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation.

objectiveIncorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. MATERIALS AND

methodsSynthesis, characterization and incorporation of DNHK into glycolic acid (PLGA) nanoparticles by nanoprecipitation method. The nanoparticles were characterized by ultraviolet-visible spectroscopy, X-ray diffraction, field emission electron microscopic scanning mansoni (FESEM), and dynamic light scattering (DLS). For the in vitro test with Schistosoma mansoni, the DNHK-loaded PLGA was diluted into the medium, and added at concentrations 10-200 µM to the culture medium containing one adult worm pair. The parasites were kept for 120 h and monitored every 24 h to evaluate their general condition, including: pairing, alterations in motor activity and mortality.

resultsThe loaded PLGA nanoparticles gave an encapsulation efficiency of 42.2% and showed spherical characteristics in monodisperse polymeric matrix. The adult worm pairs were separated after 120 h of incubation for concentrations higher than 50 µM of DNHK-loaded PLGA. The groups incubated with 150 and 200 µM of DNHK-loaded PLGA for 24 and 120 h killed 100% of adult worms, afforded LC DISCUSSION AND

conclusionsThe incorporation of DNHK-loaded showed schistosomicidal activity and allowed its sustained release. The loaded PLGA system can be administered intravenously, as well as it may be internalized by endocytosis by the target organisms.

Indexed as

4-ButyrolactoneAnimalsBenzodioxolesDrug CarriersFemaleLactic AcidLignansMaleMiceMice, Inbred BALB CNanoparticlesParticle SizePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSchistosoma mansoniSchistosomicides4-Butyrolactone6,6'-dinitrohinokininBenzodioxolesDrug CarriersLactic AcidLignansPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSchistosomicides6,6′-dinitrohinokininbiological activitynanoparticulate formulationPLGAschistosomicidal

Identifiers

PMID29172838
PMCPMC6130564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.