Evidence map›Paper›PMID 29172749›Full record

ArticleDrug delivery2017

Reduction-responsive PEtOz-SS-PCL micelle with tailored size to overcome blood-brain barrier and enhance doxorubicin antiglioma effect.

Yuling Li, Li Baiyang, Bu Leran, Wang Zhen, Xie Yandong, Du Baixiang, Zhu Dandan, Zhu Yufu, Liang Jun, Yu Rutong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuling Lia Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Li Baiyanga Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Bu Leranc Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials , School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou , PR China.
Wang Zhena Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Xie Yandonga Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Du Baixiangc Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials , School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou , PR China.
Zhu Dandanc Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials , School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou , PR China.
Zhu Yufua Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Liang Juna Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Yu Rutonga Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
Liu Hongmeia Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DOX-loaded PEtOz-SS-PCL micelles had small size and rapid drug release in reductive intracellular environments. Biodistribution and in vivo imaging studies in C6 glioma mice tumor model showed that DOX loaded PEtOz-SS-PCL43 micelles with the smallest size had superior accumulation and fast drug release in tumor sites. In vivo antitumor activity demonstrated that DOX-loaded PEtOz-SS-PCL43 micelles improved antitumor efficacy in contrast to PEtOz-SS-PCL micelles with larger size toward the orthotopic C6-Luci cells-bearing mice. This study shows great potential in tailoring the micelle size and introducing the responsive bonds or compartment for intracellular drug delivery and release in glioma treatment by designing the architecture of the polymer.

Indexed as

AnimalsAntineoplastic AgentsBiological TransportBlood-Brain BarrierCaproatesCell SurvivalDoxorubicinDrug CarriersDrug Delivery SystemsDrug LiberationGliomaLactonesMaleMiceMice, Inbred ICRMicelles2-ethyl-2-oxazolineAntineoplastic AgentsCaproatescaprolactoneDoxorubicinDrug CarriersLactonesMicellesOxazolesPolymersanti-glioma effectblood–brain barriergliomaReduction-responsivetailored size

Identifiers

PMID29172749
PMCPMC8241033

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.