ArticleJournal of abnormal psychology2018
Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use.
Article in Journal of abnormal psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Conduct problems and depressive symptoms in association with problem gambling and gaming: A systematic review.Journal of behavioral addictions · 2020Pooled it
- Is Empathy Associated with Gambling and Its Addiction? A Scoping Review of Empirical Studies.Journal of gambling studies · 2023Article
- The role of parenting in developmental trajectories of risk for adolescent substance use: a bioecological systems cascade model.Frontiers in psychology · 2023Article
- The association of amygdala-insula functional connectivity and adolescent e-cigarette use via sleep problems and depressive symptoms.Addictive behaviors · 2022Article
- A Genome-Wide Association Study Reveals aBiomedicines · 2022Article
- Electronic Cigarette Use Intentions Mediate the Association between Low Self-Control and Future Use by Internalizing Symptoms.Substance use & misuse · 2022Article
- The externalizing and internalizing pathways to marijuana use initiation: Examining the synergistic effects of impulsiveness and sensation seeking.Developmental psychology · 2021Article
- Estimating causal and time-varying effects of maternal smoking on youth smoking.Addictive behaviors · 2021Article
- Article
- Unique, long-term effects of nicotine on adolescent brain.Pharmacology, biochemistry, and behavior · 2020Review
- Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study.Journal of youth and adolescence · 2020Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
There is a limited understanding as to how specific genes impact addiction risk. Applying a developmental framework and research domain criteria (RDoC) to identify etiological pathways from genetic markers to addiction may have utility. Prior research has largely focused on externalizing pathways to substance use. Although internalizing mechanisms have received less attention, there is strong support that addiction is a longer term consequence of using substances to cope with internalizing as well as externalizing problems. This study tests whether temperament and depression mediate the association between specific genetic variants and substance use. The sample consisted of 426 adolescents from the Michigan Longitudinal Study (70.9% boys, 84.0% White). Four specific genetic variants were examined: SLC6A4 (5HTTLPR), BDNF (rs6265), NPY (rs3037354), and CRHBP (rs7728378). Childhood resiliency and behavioral control were examined as potential mediators, in addition to early adolescent depression, using a multiple-mediator path model. Resiliency and depression were supported as mediators in the association between genetic risk and later substance use. Important differences emerged across substances of abuse. Indirect effects via depression were not significant with the inclusion of aggression. Early difficulties with emotional coping may represent nonspecific neurobiological underpinnings for an internalizing pathway to addiction. (PsycINFO Database Record
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