ArticleThe Korean journal of internal medicine2019
The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study.
Article in The Korean journal of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis.Clinical and experimental medicine · 2023Pooled it
- Redefining Liver Transplantation Indications for Hepatic Malignancies in the Era of Precision Transplant Oncology: An Up-to-Date Narrative Review.Journal of clinical medicine · 2026Review
- Presentation of Metastatic Colorectal Carcinoma at a Tertiary Care Center in Pakistan.Journal of cancer & allied specialties · 2026Article
- Presentation of Metastatic Colorectal Carcinoma at a Tertiary Care Center in Pakistan.Journal of cancer & allied specialties · 2025Article
- Oophorectomy followed by postoperative chemotherapy for ovarian metastasis of colorectal cancer: a retrospective analysis.Frontiers in oncology · 2025Article
- An unusual presentation of solitary ovarian metastasis from colorectal cancer in an elderly woman: a case report.Journal of gastrointestinal oncology · 2024Article
- The tendency of segmental distribution of hepatic metastasis according to couinaud classification: a comparison of portal versus systemic route of metastatis due to primary colorectal and breast tumors.Annals of medicine and surgery (2012) · 2023Article
- The Impact of Palliative Chemotherapy on the Survival of Patients With Metastatic Colorectal Cancer in Jordan.Cureus · 2023Article
- Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer.BMC cancer · 2022Article
- Isolated synchronous Virchow lymph node metastasis of sigmoid cancer: A case report.World journal of clinical cases · 2021Article
- The impact of primary tumor location on prognosis after colorectal lung metastasectomy.International journal of colorectal disease · 2021Article
- Prognostic factors for ovarian metastases in colorectal cancer patients.World journal of surgical oncology · 2021Article
- Prognosis and factors affecting colorectal cancer with ovarian metastasis.Updates in surgery · 2021Review
- Mutational Characterization of Colorectal Cancer from Korean Patients with Targeted Sequencing.Journal of Cancer · 2021Article
- Histology and its prognostic effect onOncology letters · 2020Article
- Is it possible to predict the side of hepatic metastases according to the primary location of colorectal cancer?Polish journal of radiology · 2020Article
- Prognostic Nomogram and Patterns of Use of FOLFIRI-Aflibercept in Advanced Colorectal Cancer: A Real-World Data Analysis.The oncologist · 2019Observational
- Integrating Systemic Therapies into the Multimodality Treatment of Resectable Colorectal Liver Metastases.Gastroenterology research and practice · 2018Review
Corrections and comments
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Authors and funding
23 authors at 20 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsColorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).
methodsDemographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models.
resultsOf the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses.
conclusionPrimary tumor location influences the metastatic sites and prognosis of patients with mCRC.
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