Evidence map›Paper›PMID 29172241›Full record

ArticleDepression and anxiety2018

The impact of resilience and subsequent stressful life events on MDD and GAD.

Christina M Sheerin, Mackenzie J Lind, Emily A Brown, Charles O Gardner, Kenneth S Kendler, Ananda B Amstadter

Open access · greenAbstract readTwin Study
In one paragraph

Article in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 146 citations in OpenAlex.

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  20. Psychological Predictors of COVID-19-Related Anxiety in Vulnerable Groups.European journal of investigation in health, psychology and education · 2023
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Christina M SheerinDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID 0000-0003-3773-641X
Mackenzie J LindDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Emily A BrownDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Charles O GardnerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Ananda B AmstadterDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Virginia Commonwealth University · US

Funding

VCU NIMHD Comprehensive Center of Excellence (Project 1; PI: Strauss)P60MD002256 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CONEY, PONJOLA · 2007 to 2016
$13.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031990 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$7.7M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Genetic Contributions of Negative Valence Systems to Internalizing PathwaysR01MH101518 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ROBERSON-NAY, ROXANN · 2013 to 2016
$2.3M
Stress-induced Drinking in OEF/OIF Veterans: The Role of Combat History and PTSDR01AA020179 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2010 to 2014
$1.6M
Stress-induced drinking in Returning Soldiers: Genetic and Epigenetic MechanismsK02AA023239 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2014 to 2018
$643k
NCRR NIH HHS UL1 RR031990NIAAA NIH HHS K02 AA023239NIAAA NIH HHS R01 AA020179NIMHD NIH HHS P60 MD002256NIMH NIH HHS R01 MH101518NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

backgroundThere remains a dearth of research examining the "buffering" effect of resilience, wherein resilience at one point in time would be expected to protect an individual against development of psychopathology following future adverse life events.

methodsUsing longitudinal data from an epidemiological twin sample (N = 7463), this study tested whether resilience would act as a buffer for stressful life events (SLEs) against risk for major depressive disorder (MDD) and generalized anxiety disorder (GAD). Resilience, demographics, and psychopathology were measured at Time 1 and recent SLEs and current MDD and GAD were measured at Time 2.

resultsFinal models, controlling for demographic covariates and Time 1 diagnosis, examined the impact of Time 1 resilience, recent SLEs, their interaction, and a three-way interaction adding sex on MDD and GAD.

conclusionsThe pattern of findings was the same for MDD and GAD, wherein main effects and two-way interactions of resilience and SLEs were significant, such that greater resilience was protective even in the context of high numbers of past-year SLEs. The three-way interaction was not significant, suggesting that the relationship between SLEs and resilience on psychopathology was the same for both men and women. Findings support the conceptualization of resilience as a buffer against the impact of future life stressors on common internalizing psychopathology. Longitudinal designs and trajectory-based studies that include recurring measures of SLEs could inform conceptualizations of resilience in the context of ongoing adversity and aid in developing interventions aimed at fostering healthy adaptation in the face of stressors.

Indexed as

Life Change EventsResilience, PsychologicalAdultAnxiety DisordersFemaleHumansLongitudinal StudiesMajor Depressive DisorderMaleMiddle AgedTwinsanxietydepressionlife stresslongitudinal studiespsychologicalresilience

Identifiers

PMID29172241
PMCPMC5794521
OpenAlexW2769248139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.