Evidence map›Paper›PMID 29172228›Full record

ArticleDepression and anxiety2018

Adverse life events increase risk for postpartum psychiatric episodes: A population-based epidemiologic study.

S Meltzer-Brody, J T Larsen, L Petersen, J Guintivano, A Di Florio, W C Miller, P F Sullivan, T Munk-Olsen

Open access · goldAbstract read
In one paragraph

Article in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  18. Postpartum Psychosis: A Review of Risk Factors, Clinical Picture, Management, Prevention, and Psychosocial Determinants.Medical science monitor : international medical journal of experimental and clinical research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

S Meltzer-BrodyUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8509-408X
J T LarsenDepartment of Economics and Business Economics, The National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
L PetersenDepartment of Economics and Business Economics, The National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
J GuintivanoUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
A Di FlorioUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
W C MillerDepartment of Epidemiology, The Ohio State University, Columbus, OH, USA.
P F SullivanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
T Munk-OlsenDepartment of Economics and Business Economics, The National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
University of North Carolina at Chapel Hill · USAarhus University · DKThe Ohio State University · US

Funding

Epidemiological and Genetic Predictors of Postpartum Mood DisordersR01MH104468 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MELTZER-BRODY, SAMANTHA ERIKA · 2014 to 2017
$2.6M
NIMH NIH HHS R01 MH104468
6 · The paper itself

Abstract

backgroundTrauma histories may increase risk of perinatal psychiatric episodes. We designed an epidemiological population-based cohort study to explore if adverse childhood experiences (ACE) in girls increases risk of later postpartum psychiatric episodes.

methodsUsing Danish registers, we identified women born in Denmark between January 1980 and December 1998 (129,439 childbirths). Exposure variables were ACE between ages 0 and 15 including: (1) family disruption, (2) parental somatic illness, (3) parental labor market exclusion, (4) parental criminality, (5) parental death, (6) placement in out-of-home care, (7) parental psychopathology excluding substance use, and (8) parental substance use disorder. Primary outcome was first occurrence of in- or outpatient contact 0-6 months postpartum at a psychiatric treatment facility with any psychiatric diagnoses, ICD-10, F00-F99 (N = 651). We conducted survival analyses using Cox proportional hazard regressions of postpartum psychiatric episodes.

resultsApproximately 52% of the sample experienced ACE, significantly increasing risk of any postpartum psychiatric diagnosis. Highest risks were observed among women who experienced out-of-home placement, hazard ratio (HR) 2.57 (95% CI: 1.90-3.48). Women experiencing two adverse life events had higher risks of postpartum psychiatric diagnosis HR: 1.88 (95% CI: 1.51-2.36), compared to those with one ACE, HR: 1.24 (95% CI: 1.03-49) and no ACE, HR: 1.00 (reference group).

conclusionsACE primarily due to parental psychopathology and disability contributes to increased risk of postpartum psychiatric episodes; and greater numbers of ACE increases risk for postpartum psychiatric illness with an observed dose-response effect. Future work should explore genetic and environmental factors that increase risk and/or confer resilience.

Indexed as

AdultAdult Survivors of Child Adverse EventsCohort StudiesDenmarkDepression, PostpartumFemaleHumansPregnancyPsychotic DisordersPuerperal DisordersRegistriesRiskStress Disorders, Traumatic, AcuteYoung Adultacute stress reactionadverse life eventsmood disorderspostpartum depression

Identifiers

PMID29172228
PMCPMC6867605
OpenAlexW2766449818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.