Evidence map›Paper›PMID 29172163›Full record

ArticleNeurobiology of aging2018

Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study.

David M Cash, Martina Bocchetta, David L Thomas, Katrina M Dick, John C van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 5 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 5 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Quantifying multimodal longitudinal brain changes in presymptomatic C9orf72 disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Composite grey matter fingerprints for genetic frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 14 institutions in 6 countries.

David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Centre for Medical Image Computing, University College London, London, UK.
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
David L ThomasDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Centre for Medical Image Computing, University College London, London, UK.
Katrina M DickDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
John C van SwietenErasmus Medical Center, Rotterdam, the Netherlands.
Barbara BorroniCentre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy.
Daniela GalimbertiDepartment of Pathophysiology and Transplantation, "Dino Ferrari" Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Mario MasellisCognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
James B RoweDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Caroline GraffKarolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden; Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.
Fabrizio TagliaviniIstituto Neurologico Carlo Besta, Milan, Italy.
Giovanni B FrisoniIRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Robert LaforceUniversité Laval, Quebec, Canada.
Elizabeth FingerUniversity of Western Ontario, Ontario, Canada.
Alexandre de MendonçaFaculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Sandro SorbiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy; IRCCS Don Gnocchi, Firenze, Italy.
Martin N RossorDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Sebastien OurselinDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Centre for Medical Image Computing, University College London, London, UK.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. Electronic address: j.rohrer@ucl.ac.uk.
Genetic FTD Initiative, GENFI
UK Dementia Research Institute · GBUniversity of Brescia · ITUniversity of Toronto · CACentro San Giovanni di Dio Fatebenefratelli · ITDon Carlo Gnocchi Foundation · ITErasmus MC · NLFondazione IRCCS Istituto Neurologico Carlo Besta · ITKarolinska University Hospital · SESunnybrook Health Science Centre · CAUniversité Laval · CAUniversity of Cambridge · GBUniversity of Lisbon · PTUniversity of Milan · ITWestern University · CA

Funding

Medical Research Council MC_U105597119Medical Research Council MC_UU_00005/12Medical Research Council MC_UU_00024/1Medical Research Council MR/J009482/1Medical Research Council MR/M008525/1Medical Research Council MR/M009041/1Medical Research Council MR/M009106/1Medical Research Council MR/M023664/1Medical Research Council MR/M024873/1Wellcome TrustWellcome Trust 103838
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms of genetic FTD (mutations in C9orf72, GRN, and MAPT). Participants from the Genetic FTD Initiative (GENFI) cohort with a suitable volumetric T1 magnetic resonance imaging scan were included (319): 144 nonmutation carriers, 128 presymptomatic mutation carriers, and 47 clinically affected mutation carriers. Cross-sectional differences in GM volume between noncarriers and carriers were analyzed using voxel-based morphometry. In the affected carriers, each genetic mutation group exhibited unique areas of atrophy but also a shared network involving the insula, orbitofrontal lobe, and anterior cingulate. Presymptomatic GM atrophy was observed particularly in the thalamus and cerebellum in the C9orf72 group, the anterior and medial temporal lobes in MAPT, and the posterior frontal and parietal lobes as well as striatum in GRN. Across all presymptomatic carriers, there were significant decreases in the anterior insula. These results suggest that although there are important differences in atrophy patterns for each group (which can be seen presymptomatically), there are also similarities (a fronto-insula-anterior cingulate network) that help explain the clinical commonalities of the disease.

Indexed as

AdultAgedAtrophyC9orf72 ProteinCohort StudiesFemaleFrontotemporal DementiaGray MatterHeterozygoteHumansIntercellular Signaling Peptides and ProteinsMagnetic Resonance ImagingMaleMiddle AgedMutationOrgan SizeC9orf72 ProteinC9orf72 protein, humanGRN protein, humanIntercellular Signaling Peptides and ProteinsMAPT protein, humanProgranulinstau ProteinsAtrophyFrontotemporal dementiaMagnetic resonance imagingPreclinical dementiaVoxel-based morphometry

Identifiers

PMID29172163
PMCPMC5759893
OpenAlexW2766970894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.