ArticleJournal of photochemistry and photobiology. B, Biology2018
Potentiation by potassium iodide reveals that the anionic porphyrin TPPS4 is a surprisingly effective photosensitizer for antimicrobial photodynamic inactivation.
Article in Journal of photochemistry and photobiology. B, Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Laser fluorescence assessment of dental caries arrest with two silver fluoride agents in patients with special needs- a preliminary report.Lasers in medical science · 2024Article
- Simultaneous effect of medicinal plants as natural photosensitizers and low-level laser on photodynamic inactivation.Lasers in medical science · 2024Article
- Refining antimicrobial photodynamic therapy: effect of charge distribution and central metal ion in fluorinated porphyrins on effective control of planktonic and biofilm bacterial forms.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Sulfonamide Porphyrins as Potent Photosensitizers against Multidrug-ResistantMolecules (Basel, Switzerland) · 2023Article
- Porphyrin Polymers BearingPolymers · 2022Article
- Antimicrobial Photodynamic Effect of Cross-Kingdom Microorganisms with Toluidine Blue O and Potassium Iodide.International journal of molecular sciences · 2022Article
- Development of a Polymeric Film Entrapping Rose Bengal and Iodide Anion for the Light-Induced Generation and Release of Bactericidal Hydrogen Peroxide.International journal of molecular sciences · 2022Article
- Synergistic Effect of Combination of a Temoporfin-Based Photodynamic Therapy with Potassium Iodide or Antibacterial Agents on Oral Disease Pathogens In Vitro.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins.Antibiotics (Basel, Switzerland) · 2022Article
- In Vitro Potentiation of Antimicrobial Photodynamic Inactivation by Addition of Potassium Iodide.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Porphyrin-Schiff Base Conjugates Bearing Basic Amino Groups as Antimicrobial Phototherapeutic Agents.Molecules (Basel, Switzerland) · 2021Article
- Photodynamic Inactivation ofPolymers · 2021Article
- Antimicrobial Photodynamic Approach in the Inactivation of Viruses in Wastewater: Influence of Alternative Adjuvants.Antibiotics (Basel, Switzerland) · 2021Article
- Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect.Molecular therapy oncolytics · 2020Review
- Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?Antibiotics (Basel, Switzerland) · 2020Review
- The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action againstAntibiotics (Basel, Switzerland) · 2019Article
- Tetracyclines: light-activated antibiotics?Future medicinal chemistry · 2019Review
- New Materials Based on Cationic Porphyrins Conjugated to Chitosan or Titanium Dioxide: Synthesis, Characterization and Antimicrobial Efficacy.International journal of molecular sciences · 2019Article
- Can light-based approaches overcome antimicrobial resistance?Drug development research · 2019Review
- Comparison of thiocyanate and selenocyanate for potentiation of antimicrobial photodynamic therapy.Journal of biophotonics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
We recently reported that addition of the non-toxic salt, potassium iodide can potentiate antimicrobial photodynamic inactivation of a broad-spectrum of microorganisms, producing many extra logs of killing. If the photosensitizer (PS) can bind to the microbial cells, then delivering light in the presence of KI produces short-lived reactive iodine species, while if the cells are added after light the killing is caused by molecular iodine produced as a result of singlet oxygen-mediated oxidation of iodide. In an attempt to show the importance of PS-bacterial binding, we compared two charged porphyrins, TPPS4 (thought to be anionic and not able to bind to Gram-negative bacteria) and TMPyP4 (considered cationic and well able to bind to bacteria). As expected TPPS4+light did not kill Gram-negative Escherichia coli, but surprisingly when 100mM KI was added, it was highly effective (eradication at 200nM+10J/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.