ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2018
Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinical characteristics and IgE-binding protein profiles of patients with buckwheat allergy in China.The World Allergy Organization journal · 2026Article
- Identification of a Candidate IgE-Binding Maize Protein in a Patient With Corn-Dependent Exercise-Induced Anaphylaxis: A Case Report.Case reports in immunology · 2026Article
- Buckwheat Allergy in Asia.Current allergy and asthma reports · 2024Review
- Study on the reduction of Tartary buckwheat allergenicity duringFood chemistry: X · 2023Article
- Characterization of 2S albumin allergenic proteins for anaphylaxis in common buckwheat.Food chemistry. Molecular sciences · 2022Article
- A Review on Epidemiological and Clinical Studies on Buckwheat Allergy.Plants (Basel, Switzerland) · 2021Review
- Allergens of Regional Importance in Korea.Frontiers in allergy · 2021Review
- Understanding buckwheat allergies for the management of allergic reactions in humans and animals.Breeding science · 2020Article
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
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9 authors.
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Abstract
backgroundBuckwheat (Fagopyrum esculentum) has become increasingly popular as a healthy food in Europe. However, for sensitized individuals, consumption can cause anaphylactic reactions. The aim of this study was to identify individual well-characterized buckwheat allergens for component-resolved diagnosis.
methodsPatients were selected by positive skin prick test to buckwheat and divided into two groups: (1) sensitized to buckwheat without clinical symptoms and (2) buckwheat allergy. Buckwheat proteins were extracted from raw buckwheat seeds, purified applying a combination of protein precipitation and chromatographic methods, and analyzed by IgE immunoblotting and ELISA.
resultsBuckwheat-allergic patients had a significantly larger median skin prick test weal diameter for buckwheat than the sensitized group and the positive control. Also, IgE immunoblotting clearly showed a distinct pattern in sera from allergic patients when compared to sensitized individuals. Several IgE-reactive proteins were purified from crude buckwheat extract, namely legumin (Fag e 1 plus its large subunit), Fag e 2 (2S albumin), and newly identified Fag e 5 (vicilin-like) as well as hevein-like antimicrobial peptides, designated Fag e 4. All four allergens showed superior diagnostic precision compared to extract-based ImmunoCAP with high sensitivity as well as high specificity.
conclusionsPatients with clinical symptoms clearly show a distinct allergen recognition pattern. We characterized a buckwheat vicilin-like protein as a new relevant marker allergen, designated Fag e 5. Additionally, another new allergen, Fag e 4, potentially important for cross-reactivity to latex was added to the allergen panel of buckwheat. Further, our data show that the full-length legumin comprising both, large and small subunit should be applied for component-resolved diagnosis. Our data indicate that concomitant sensitization to legumin, Fag e 2 and Fag e 5, predicts buckwheat allergy.
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