ArticleMicrobiology (Reading, England)2017
Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390.
Article in Microbiology (Reading, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Type VIIb secretion systems in Lactobacillales: insights from streptococci and enterococci.Journal of bacteriology · 2026Review
- TheMicrobiology (Reading, England) · 2025Article
- Distinct immunity protein families mediate compartment-specific neutralization of a bacterial toxin.Cell reports · 2025Article
- High-throughput functional analysis provides novel insight into type VII secretion inOpen biology · 2024Article
- Interbacterial competition mediated by the type VIIb secretion system.Microbiology (Reading, England) · 2023Review
- The Type VII Secretion System ofAnnual review of microbiology · 2021Article
- Activation of a bacterial killing machine.PLoS genetics · 2021Article
- The type VII secretion system protects Staphylococcus aureus against antimicrobial host fatty acids.Scientific reports · 2020Article
- The type VII secretion system protects Staphylococcus aureus against antimicrobial host fatty acids.Scientific reports · 2020Article
- A membrane-depolarizing toxin substrate of theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- EssC is a specificity determinant for Staphylococcus aureus type VII secretion.Microbiology (Reading, England) · 2018Article
- Functional analysis of the EsaB component of theMicrobiology (Reading, England) · 2017Article
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The Staphylococcus aureus type VII protein secretion system (T7SS) plays important roles in virulence and intra-species competition. Here we show that the T7SS in strain RN6390 is activated by supplementing the growth medium with haemoglobin, and its cofactor haemin (haem B). Transcript analysis and secretion assays suggest that activation by haemin occurs at a transcriptional and a post-translational level. Loss of T7 secretion activity by deletion of essC results in upregulation of genes required for iron acquisition. Taken together these findings suggest that the T7SS plays a role in iron homeostasis in at least some S. aureus strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.