Evidence map›Paper›PMID 29171820›Full record

ReviewThe New England journal of medicine2017

Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy.

Robert Zeiser, Bruce R Blazar

3 registry-linked trialsAbstract readReview
In one paragraph

Review in The New England journal of medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 762 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
762citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04290429 early_phase1completednot on this map

Analysis of the Effect of Teduglutide Treatment on Intestinal Malabsorption and Paneth Cell Numbers in Patients With Steroid-refractory Gastrointestinal Graft Versus Host Disease (SR-GI-GVHD).

TypeinterventionalSponsorUniversity of FreiburgRan2017 to 2019Enrolled6ConditionsGraft Versus Host DiseaseArmsTeduglutide
NCT04342442 completednot on this map

Investigation of Novel Targetable Kinases in Steroid-refractory Acute Graft-versus-host Disease

TypeobservationalSponsorUniversity of FreiburgRan2017 to 2019Enrolled24ConditionsGraft Versus Host Disease
NCT07708987 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

A Phase II Clinical Trial of Standardized Withaferin-A for the Treatment of Steroid Refractory Acute Graft Versus Host Disease

TypeinterventionalSponsorTata Memorial CentreRan2023 to 2028Enrolled34ConditionsHematological Malignancy, GVHD - Graft-Versus-Host Disease, Steriod RefractoryArmsStandardized Withaferin A (SWA)
3 · Its place in the literature

Who cites it

762 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Review
  15. Biochemistry and biophysics reports · 2026
    Review
  16. Hyperacute Graft-Versus-Host Disease.Bone marrow transplantation · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Article

702 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Robert ZeiserFrom the Department of Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Freiburg University Medical Center, Freiburg, Germany (R.Z.); and the Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis (B.R.B.).
Bruce R BlazarFrom the Department of Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Freiburg University Medical Center, Freiburg, Germany (R.Z.); and the Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis (B.R.B.).

Funding

Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
Project 3: Humoral Targets and B Cell Biology in Chronic Graft-vs.-Host DiseaseP01CA142106 · NCI · DANA-FARBER CANCER INST · PI RITZ, JEROME · 2009 to 2019
$17.5M
T-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4M
In Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4M
NCI NIH HHS P01 CA065493NCI NIH HHS P01 CA142106NHLBI NIH HHS R01 HL056067NIAID NIH HHS P01 AI056299NIAID NIH HHS R37 AI034495
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Graft vs Host DiseaseImmunosuppression TherapyAcute DiseaseAnimalsDisease Models, AnimalGlucocorticoidsHematopoietic Stem Cell TransplantationHumansMiceT-LymphocytesTransplantation, HomologousTransplantation ImmunologyGlucocorticoids

Identifiers

PMID29171820
PMCPMC6034180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.