ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Sex-related relationships between uric acid and target organ damage in hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Antihypertensive drugs for hyperuricemia in patients with hypertension: a systematic review and network meta-analysis of Chinese trials.BMC cardiovascular disorders · 2025Pooled it
- Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study.Scientific reports · 2023Trial
- Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases.Scientific reports · 2025Article
- Association between renal function and arterial stiffness among women with systemic lupus erythematosus or antiphospholipid syndrome.Cardiology journal · 2025Article
- Impact of Chronic Kidney Disease and Gout on End-Stage Renal Disease in Type 2 Diabetes: Population-Based Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2024Article
- Life's Essential 8, Life's Simple 7 and the odds of hyperuricaemia: results from the China Multi-Ethnic Cohort Study.Rheumatology advances in practice · 2024Article
- Development and validation of a prediction model for hyperuricemia risk in hypertensive patients.American journal of cardiovascular disease · 2024Article
- Sex-related differences for uric acid in the prediction of cardiovascular events in essential hypertension. A population prospective study.Cardiovascular diabetology · 2023Article
- The association among uric acid, microalbumin and estimated glomerular filtration rate in hypertensive patients: a case control study.BMC cardiovascular disorders · 2023Article
- Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China.Frontiers in endocrinology · 2023Article
- Assessment of the influence on left ventricle by potassium oxonate and hypoxanthine-induced chronic hyperuricemia.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension.Frontiers in endocrinology · 2023Article
- Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage.Journal of clinical medicine · 2022Article
- Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study.BMJ open · 2022Article
- The Role of Uric Acid in Acute and Chronic Coronary Syndromes.Journal of clinical medicine · 2021Review
- Prevalence and Risk Factors Associated with Hyperuricemia in the Pearl River Delta, Guangdong Province, China.Risk management and healthcare policy · 2021Article
- The Prevalence, Distribution, and Extent of Subclinical Atherosclerosis and Its Relation With Serum Uric Acid in Hypertension Population.Frontiers in cardiovascular medicine · 2021Article
- Association between uric acid lowering and renal function progression: a longitudinal study.PeerJ · 2021Article
- Food Consumption is Associated with Hyperuricemia in Boys.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Article
- Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension.Journal of geriatric cardiology : JGC · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneous results have been obtained in the relationship between serum uric acid (SUA) and target organ damage (TOD) in patients with hypertension. Clinic blood pressure, SUA, and cardiac, arterial (carotid and aortic), and renal TOD were assessed in 762 consecutive patients with hypertension. Hyperuricemia was defined as an SUA >7.0 in men and >6.0 mg/dL in women. Men with hyperuricemia compared with those with normal SUA showed lower estimated glomerular filtration rates and E/A ratios and a higher prevalence of carotid plaques. Women with hyperuricemia showed lower estimated glomerular filtration rates and E/A ratios and a higher intima-media thickness. Except for pulse wave velocity, all TODs significantly correlated with SUA. However, at multivariate analysis, only estimated glomerular filtration rate was significantly determined by SUA. Our data provide evidence on the role of SUA in the development of TOD only in the case of renal alteration. It is likely that SUA may indirectly act on the other TODs through the increase in blood pressure and the decrease in glomerular filtration rate.
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Registered trials
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