ArticleParasite immunology2017
A T-cell diagnostic test for cystic echinococcosis based on Antigen B peptides.
Article in Parasite immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Peptide MegaPools Approach to Evaluate the Dengue-Specific CD4 and CD8 T-Cell Response.Pathogens (Basel, Switzerland) · 2025Article
- Stage-Specific Immune Responses to AgB T-Peptides in Patients with Cystic Echinococcosis.Infectious disease reports · 2025Article
- Evaluation of the Local and Peripheral Immune Responses in Patients with Cystic Echinococcosis.Pathogens (Basel, Switzerland) · 2024Article
- Antigen discovery by bioinformatics analysis and peptide microarray for the diagnosis of cystic echinococcosis.PLoS neglected tropical diseases · 2023Article
- A review of hypersensitivity methods to detect immune responses to SARS-CoV-2.Methods in microbiology · 2022Article
- Accuracy of an experimental whole-blood test for detecting reactivation of echinococcal cysts.PLoS neglected tropical diseases · 2021Article
- In-vitro evaluation of the immunomodulatory effects of Baricitinib: Implication for COVID-19 therapy.The Journal of infection · 2021Article
- Species specificity preliminary evaluation of an IL-4-based test for the differential diagnosis of human echinococcosis.Parasite immunology · 2020Article
- Severe chest allodynia as an unusual first presentation of hydatid disease: a case report.BMC infectious diseases · 2019Article
- Evaluation of the recombinant antigens B2t and 2B2t, compared with hydatid fluid, in IgG-ELISA and immunostrips for the diagnosis and follow up of CE patients.PLoS neglected tropical diseases · 2018Article
- A T-cell diagnostic test for cystic echinococcosis based on Antigen B peptides.Parasite immunology · 2017Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystic echinococcosis (CE) immunodiagnosis is still imperfect. We recently set-up a whole-blood test based on the interleukin (IL)-4 response to the native Antigen B (AgB) of Echinococcus granulosus. However, AgB is encoded by a multigene family coding for five putative subunits. Therefore, the aims of this study were to analyse the IL-4 response to peptides spanning the immunodominant regions of the five AgB subunits and to evaluate the accuracy of this assay for CE diagnosis. Peptides corresponding to each subunit were combined into five pools. A pool containing all peptides was also used (total pool). IL-4 evaluated by enzyme-linked immunosorbent assay was significantly higher in patients with CE compared to those without (NO-CE subjects) when whole-blood was stimulated with AgB1 and with the total pool. Moreover, IL-4 levels in response to the total pool were significantly increased in patients with active cysts. Receiver Operator Curve analysis identified a cut-off point of 0.59 pg/mL predicting active cysts diagnosis with 71% sensitivity and 82% specificity in serology-positive CE patients. These data, if confirmed in a larger cohort, offer the opportunity to develop new diagnostic tools for CE based on a standardized source of AgB as the peptides.
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