Evidence map›Paper›PMID 29170977›Full record

ArticlePurinergic signalling2018

Species differences and mechanism of action of A

Lili Du, Zhan-Guo Gao, Silvia Paoletta, Tina C Wan, Elizabeth T Gizewski, Samantha Barbour, Jacobus P D van Veldhoven, Adriaan P IJzerman, Kenneth A Jacobson, John A Auchampach

Abstract read
In one paragraph

Article in Purinergic signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Bitopic AJournal of medicinal chemistry · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Lipid Trolling to Optimize AJournal of medicinal chemistry · 2024
    Article
  7. Extrahelical Binding Site for a 1Molecular pharmacology · 2024
    Article
  8. Article
  9. Species dependence of APurinergic signalling · 2023
    Review
  10. Structure-Activity Studies of 1Journal of medicinal chemistry · 2022
    Article
  11. Characterization of Dual-Acting AACS pharmacology & translational science · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Design and in Vivo Characterization of AJournal of medicinal chemistry · 2019
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lili DuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 200892-0810, USA.
Silvia PaolettaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 200892-0810, USA.
Tina C WanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Elizabeth T GizewskiDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Samantha BarbourDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Jacobus P D van VeldhovenDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands.
Adriaan P IJzermanDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 200892-0810, USA.
John A AuchampachDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. jauchamp@mcw.edu.
Medical College of Wisconsin · USNational Institutes of Health · USLeiden University · NL

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Role of Adenosine Receptors in Tissue ProtectionR01HL077707 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2005 to 2014
$3.4M
EET-Induced Cardioprotection: Role of Opioids and Nitric Oxide (NO)R01HL111392 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2012 to 2016
$2.2M
Adenosine Signaling During Post-Infarction Remodeling and Heart FailureR01HL133589 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL077707NHLBI NIH HHS R01 HL111392NHLBI NIH HHS R01 HL133589NIDDK NIH HHS Z01 DK011117-26
6 · The paper itself

Abstract

Activity of the A

Indexed as

Adenosine A3 Receptor AgonistsAminoquinolinesAnimalsDogsHumansImidazolesMiceMolecular Docking SimulationRabbitsReceptor, Adenosine A3Species SpecificityAdenosine A3 Receptor AgonistsAminoquinolinesImidazolesN-(3,4-dichlorophenyl)-2-cyclohexyl-1H-imidazo(4,5-c)quinolin-4-amineReceptor, Adenosine A3Adenosine receptorAllosteric modulationG protein-coupled receptorNucleoside

Identifiers

PMID29170977
PMCPMC5842153
OpenAlexW2770339311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.