Evidence map›Paper›PMID 29170860›Full record

ArticleObesity surgery2018

γ-Glutamyltransferase Fractions in Obese Subjects with Type 2 Diabetes: Relation to Insulin Sensitivity and Effects of Bariatric Surgery.

Maria Franzini, Veronica Musetti, Daniela Guarino, Laura Caponi, Aldo Paolicchi, Michele Emdin, Ele Ferrannini, Monica Nannipieri

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Article in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Maria FranziniDepartment of Translational Research, University of Pisa, Pisa, Italy.
Veronica MusettiDepartment of Translational Research, University of Pisa, Pisa, Italy.
Daniela GuarinoDepartment of Clinical and Experimental Medicine, University of Pisa, Via Savi 8, 56126, Pisa, Italy.
Laura CaponiDepartment of Translational Research, University of Pisa, Pisa, Italy.
Aldo PaolicchiDepartment of Translational Research, University of Pisa, Pisa, Italy.
Michele EmdinSant'Anna School of Advanced Study - Pisa and CNR Institute of Clinical Physiology, Pisa, Italy.
Ele FerranniniCNR Institute of Clinical Physiology, Pisa, Italy.
Monica NannipieriDepartment of Clinical and Experimental Medicine, University of Pisa, Via Savi 8, 56126, Pisa, Italy. monica.nannipieri@dmi.unipi.it.ORCID 0000-0003-1346-2813
University of Pisa · ITIstituto di Fisiologia Clinica · ITScuola Superiore Sant'Anna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesGamma-glutamyltranspeptidase (GGT) levels are an independent risk marker for the development of type 2 diabetes (T2DM). We investigated the relationship between the newly identified serum GGT fractions and glucose metabolism in obese subjects before and after bariatric surgery. SUBJECTS/

methodsTwenty-nine T2DM subjects, wait-listed for Roux-en-Y gastric bypass (RYGB; n = 21) or laparoscopic sleeve gastrectomy (LSG; n = 8), received a 5-h mixed meal test before (T0), 15 days (T15), and 1 year after surgery (T365). Insulin sensitivity was assessed by the OGIS index and β-cell function by C-peptide analysis; fractional GGT (b-, s-, m-, and f-GGT) analysis was performed by gel-filtration chromatography.

resultsAt T15, total GGT activity decreased by 40% after LSG (p = 0.007) but remained unchanged after RYGB. At T365, all patients showed a reduction in total GGT, in particular b-GGT (≥ 60%) and m-GGT (≥ 50%). In patients with biopsy-proven steatohepatitis (n = 10), total, b-, s-, and m-GGT fractions at T0 were significantly higher than in patients with low-grade steatosis (p = 0.016, 0.0003, and 0.005, respectively); at T365, there was a significant fall in total GGT as well as in each fraction in both groups. In a multiple regression model, b-GGT was the only fraction related to insulin sensitivity (p = 0.016; β coeff. = - 14.0) independently of BMI, fasting glucose, and triglycerides.

conclusionsWhile GGT activity is generally associated with impaired glucose metabolism, fractional GGT analysis showed that the b-GGT fraction specifically and independently tracks with insulin resistance.

Indexed as

Bariatric SurgeryAdultAgedC-PeptideDiabetes Mellitus, Type 2FastingFatty LiverFemalegamma-GlutamyltransferaseGastrectomyGastric BypassHumansInsulin ResistanceMaleMiddle AgedObesityC-Peptidegamma-GlutamyltransferaseTriglyceridesB-GGT fractionGamma-glutamyltransferaseInsulin sensitivityNASH

Identifiers

PMID29170860
OpenAlexW2769953287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.