Evidence map›Paper›PMID 29170792›Full record

Trial reportWorld journal of urology2018

Prospective comparison among three intrarectal anesthetic treatments combined with periprostatic nerve block during transrectal ultrasonography-guided prostate biopsy.

R A Valdez-Flores, J G Campos-Salcedo, J J Torres-Gomez, A Sedano-Lozano, J Parés-Hipólito, L M Shelton, A Canizalez-Román, M A Valdez-Flores

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03859804 (Comparison of Pain Levels in Fusion Prostate Biopsy and Standard TRUS-Guided Biopsy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03859804 nacompletednot on this map

Comparison of Pain Levels in Fusion Prostate Biopsy and Standard TRUS-Guided Biopsy

TypeinterventionalSponsorTC Erciyes UniversityRan2016 to 2019Enrolled252ConditionsPain Due to Certain Specified Procedures, Prostate Cancer, BiopsyArmsStandard transrectal 12 core biopsy, MRI- US fusion prostate biopsy (FPB)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Comparison of pain levels in fusion prostate biopsy and standard TRUS-Guided biopsy.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

R A Valdez-FloresUrology Department, Central Military Hospital, Mexico City, Mexico.
J G Campos-SalcedoUrology Department, Central Military Hospital, Mexico City, Mexico.
J J Torres-GomezUrology Department, Central Military Hospital, Mexico City, Mexico.
A Sedano-LozanoUrology Department, Central Military Hospital, Mexico City, Mexico.
J Parés-HipólitoResearch Unit, Regional Military Hospital, San Luis Potosí, Mexico.
L M SheltonRadboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
A Canizalez-RománResearch Center Applied to Public Health, School of Medicine, Autonomous University of Sinaloa, Campus 2. Av. Cedros y Calle Sauces. Fracc. Los Fresnos, 80019, Culiacan, Sinaloa, Mexico.
M A Valdez-FloresResearch Center Applied to Public Health, School of Medicine, Autonomous University of Sinaloa, Campus 2. Av. Cedros y Calle Sauces. Fracc. Los Fresnos, 80019, Culiacan, Sinaloa, Mexico. marco.valdez@live.com.mx.
Hospital Central Militar · MXAutonomous University of Sinaloa · MXPediatric Hospital of Sinaloa · MXRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent trends in prostate biopsy analgesia suggest a combination anesthetic to provide better pain relief than periprostatic nerve block (PPNB) alone. This study aimed to demonstrate the efficacy and safety of three intrarectal local anesthesia (IRLA) combined with PPNB in patients undergoing transrectal ultrasonography (TRUS)-guided prostate biopsy.

methodsIn this prospective, randomized study, 120 prostate biopsy patients were equally divided into four IRLA groups: group 1 (placebo) received simple lubrication; group 2 received 2% lidocaine gel; group 3 received 100 mg indomethacin suppository and group 4 received 5% prilocaine/lidocaine (EMLA) cream. PPNB with 2% lidocaine was applied in all groups. A ten-point visual analog scale evaluated both pain associated with the probe insertion and pain associated with prostate sampling. Adverse effects or complications due to anesthesia during and after the procedure were documented.

resultsCompared with group 1, groups 3 and 4 had significantly lower pain scores at both probe insertion and prostate sampling while group 2 showed no significant differences at both pain scores. Moreover, group 4 showed significantly lower pain scores at probe insertion compared to group 3, while no significant difference was observed at prostate sampling. Mild complications were observed in all groups with no significant difference in the incidence of complications between groups.

conclusionIntrarectal application of EMLA cream is a more efficient pain reduction than either 2% lidocaine gel or 100 mg indomethacin suppository when applied combined with PPNB. This combination represents an effective option of pain relief for patients undergoing TRUS-guided prostate biopsy.

Indexed as

Administration, TopicalAgedAnesthesia, LocalAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalBiopsy, Large-Core NeedleEndosonographyHumansImage-Guided BiopsyIndomethacinLidocaineLidocaine, Prilocaine Drug CombinationMaleMiddle AgedNerve BlockPain MeasurementAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalIndomethacinLidocaineLidocaine, Prilocaine Drug CombinationPrilocaineAnesthesiaBiopsyIndomethacinLidocainePrilocaineProstate cancer

Identifiers

PMID29170792
OpenAlexW2768407893

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.