ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2019
Trauma-induced coagulopathy upon emergency room arrival: still a significant problem despite increased awareness and management?
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Plasma Transfusion Practice in Adult Surgical Patients: Systematic Review of the Literature.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Pooled it
- Gelatin 4% and hydroxyethyl starch (130/0.42) impair clot formation in a human ex vivo whole-blood resuscitation model.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma.Scientific reports · 2025Observational
- Liquid biopsy in orthopedic trauma: exosomes as functional mediators and mechanistic indicators in post-traumatic complications.Frontiers in medicine · 2025Review
- Analysis of factors influencing the surgical treatment outcomes of spinal injuries in polytrauma patients.Annals of medicine and surgery (2012) · 2024Article
- Update on the pathophysiology and management of acute trauma hemorrhage and trauma-induced coagulopathy based upon viscoelastic testing.Clinical and experimental emergency medicine · 2024Article
- Does an early, balanced resuscitation strategy reduce the incidence of hypofibrinogenemia in hemorrhagic shock?Trauma surgery & acute care open · 2024Article
- Profile of injuries in recent warfare.The journal of trauma and acute care surgery · 2023Article
- Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGUCritical care (London, England) · 2023Article
- Trauma-induced pulmonary thromboembolism: What's update?Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Review
- Immunopathophysiology of trauma-related acute kidney injury.Nature reviews. Nephrology · 2021Review
- The European Perspective on the Management of Acute Major Hemorrhage and Coagulopathy after Trauma: Summary of the 2019 Updated European Guideline.Journal of clinical medicine · 2021Article
- Simplified treatment algorithm for the management of trauma-induced hemorrhage without viscoelastic testing.Trauma surgery & acute care open · 2021Article
- The Diagnosis and Treatment of Acute Traumatic Bleeding and Coagulopathy.Deutsches Arzteblatt international · 2019Review
- Comparison of ROTEM parameters from venous and intraosseous blood.Scientific reports · 2019Observational
- [The TraumaRegister DGU® dataset, its development over 25 years and advances in the care of severely injured patients].Der Unfallchirurg · 2018Review
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9 authors.
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Abstract
purposeOver the last decade, the pivotal role of trauma-induced coagulopathy has been described and principal drivers have been identified. We hypothesized that the increased knowledge on coagulopathy of trauma would translate into a more cautious treatment, and therefore, into a reduced overall incidence rate of coagulopathy upon ER admission. PATIENTS AND
methodsBetween 2002 and 2013, 61,212 trauma patients derived from the TraumaRegister DGU® had a full record of coagulation parameters and were assessed for the presence of coagulopathy. Coagulopathy was defined by a Quick's value < 70% and/or platelet counts < 100,000/µl upon ER admission. For each year, the incidence of coagulopathy, the amount of pre-hospital administered i.v.-fluids and transfusion requirements were assessed.
resultsCoagulopathy upon ER admission was present in 24.5% of all trauma patients. Within the years 2002-2013, the annual incidence of coagulopathy decreased from 35 to 20%. Even in most severely injured patients (ISS > 50), the incidence of coagulopathy was reduced by 7%. Regardless of the injury severity, the amount of pre-hospital i.v.-fluids declined during the observed period by 51%. Simultaneously, morbidity and mortality of severely injured patients were on the decrease.
conclusionDuring the 12 years observed, a substantial decline of coagulopathy has been observed. This was paralleled by a significant decrease of i.v.-fluids administered in the pre-hospital treatment. The reduced presence of coagulopathy translated into decreased transfusion requirements and mortality. Nevertheless, especially in the most severely injured patients, posttraumatic coagulopathy remains a frequent and life-threatening syndrome.
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