Evidence map›Paper›PMID 29170786›Full record

ReviewThe Analyst2017

Recent advances in the use of microfluidic technologies for single cell analysis.

Travis W Murphy, Qiang Zhang, Lynette B Naler, Sai Ma, Chang Lu

Abstract readReview
In one paragraph

Review in The Analyst, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Dual inhibition of mTOR and calcineurin pathways mitigates missing self-induced NK cell-mediated microvascular rejection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Advanced Microfluidics for Single Cell-Based Cancer Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Review
  7. Opportunities and challenges in the application of single-cell transcriptomics in plant tissue research.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Exploring Single-Cell Exposomics by Mass Spectrometry.Environmental science & technology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Travis W MurphyDepartment of Chemical Engineering, Virginia Tech, Blacksburg, VA 24061, USA. changlu@vt.edu.
Qiang Zhang
Lynette B Naler
Sai Ma
Chang Lu

Funding

Probing dynamics in protein-DNA interactions during disease development using sinR01EB017235 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2014 to 2017
$1.3M
Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samplesR33CA214176 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2017 to 2019
$1.2M
Ultrasensitive microfluidic ChIP-MethylC-seq for integrative analysis of histone modification and DNA methylationR21HG009256 · NHGRI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG · 2016 to 2018
$604k
Single cell epigenomic study based on microfluidic chromatin immunoprecipitationR21HG008623 · NHGRI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LU, CHANG, TAN, KAI · 2015 to 2016
$423k
NCI NIH HHS R33 CA214176NHGRI NIH HHS R21 HG008623NHGRI NIH HHS R21 HG009256NIBIB NIH HHS R01 EB017235
6 · The paper itself

Abstract

The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a broad view of the recent microfluidic developments in single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

Identifiers

PMID29170786
PMCPMC5839671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.